Reactome | Prostanoid ligand receptors

Prostanoid ligand receptors

Stable Identifier

R-HSA-391908

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Fatty acid cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2) from which the prostanoids PGD2, PGE2, PGF2alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are derived. Based on the agonist potencies, five prostanoid receptors are recognized and correspondingly named DP, EP, FP, IP and TP receptors (Coleman RA et al, 1994). Additionally, EP receptors contains four subtypes, termed EP1, EP2, EP3 and EP4; the DP receptor also has two subtypes, DP1 and DP2 (CRTH2).

Literature References

PubMed ID	Title	Journal	Year
7938166	International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes Smith, WL, Narumiya, S, Coleman, RA	Pharmacol Rev	1994