Reactome | p-Y588,Y594-EPHA2 [plasma membrane]

p-Y588,Y594-EPHA2 [plasma membrane]

Stable Identifier

R-HSA-3928380

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ephrin type-A receptor 2 ecNumber2.7.10.1/ecNumber, EPHA2_HUMAN, EPHA2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH receptors autophosphorylate (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        EPHA binds TIAM1 (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        SFKs phosphorylate VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        p-EPHs bind VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        NGEF binds EPHA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        SFKs phosphorylate NGEF (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
      - p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y588,Y594-EPHA2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29317 EPHA2

Gene Names

EPHA2, ECK

Chain

signal peptide:1-23, chain:24-976

Reference Genes

BioGPS Gene:1969 EPHA2

COSMIC (genes):EPHA2 EPHA2

CTD Gene:1969 EPHA2

dbSNP Gene:1969 EPHA2

ENSEMBL:ENSG00000142627 EPHA2

HGNC:3386 EPHA2

KEGG:hsa:1969 EPHA2

Monarch:1969 EPHA2

NCBI Gene:1969 EPHA2

OMIM:176946 EPHA2

UCSC:P29317 EPHA2

Reference Transcript

RefSeq:NM_004431.4 EPHA2

Other Identifiers

11717619_at

11748166_a_at

1379_at

16682098

1969

203499_PM_at

203499_at

2397949

2397950

2397952

2397953

2397956

2397957

2397958

2397959

2397960

2397961

2397962

2397963

2397964

2397965

2397966

2397968

2397969

2397974

2397975

2397976

2397978

2397979

2397980

7912706

A_23_P149281

GE57994

GO:0001501

GO:0001525

GO:0001568

GO:0001570

GO:0001618

GO:0001649

GO:0001818

GO:0002043

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005515

GO:0005524

GO:0005886

GO:0005925

GO:0006468

GO:0006915

GO:0006954

GO:0007155

GO:0007169

GO:0008630

GO:0009986

GO:0010591

GO:0012501

GO:0014028

GO:0016020

GO:0016477

GO:0016525

GO:0016740

GO:0019838

GO:0021915

GO:0030027

GO:0030154

GO:0030182

GO:0030216

GO:0030316

GO:0030335

GO:0031256

GO:0031258

GO:0032587

GO:0032682

GO:0033598

GO:0033628

GO:0036342

GO:0042995

GO:0043235

GO:0043535

GO:0045296

GO:0045765

GO:0046058

GO:0046718

GO:0046849

GO:0048013

GO:0048320

GO:0048514

GO:0048570

GO:0048856

GO:0048870

GO:0050830

GO:0055086

GO:0060035

GO:0060089

GO:0060326

GO:0060444

GO:0070160

GO:0070161

GO:0070309

GO:0070372

GO:0070848

GO:0072659

GO:0090630

GO:0098542

GO:0098772

GO:0140096

GO:0140677

GO:1901135

GO:1901491

GO:1903078

GO:1903348

GO:1904238

HMNXSV003027719

ILMN_1699354

M59371_at

PH_hs_0010271

TC01002258.hg

g4758277_3p_at

Participates

as a member of

p-EPHAs [plasma membrane] (Homo sapiens)

Other forms of this molecule

EPHA2 [plasma membrane]

Inferred To

phospho-EPHA2 [plasma membrane] (Canis familiaris)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Bos taurus)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Danio rerio)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Drosophila melanogaster)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Gallus gallus)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Mus musculus)

phospho-p-Y588,Y594-EPHA2 [plasma membrane] (Sus scrofa)

phospho-Epha2 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 588

Coordinate

588

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 594

Coordinate

594

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_004422.2

ZINC - World Drugs

EPHA2_HUMAN

Guide to Pharmacology - Targets

1822

OpenTargets

ENSG00000142627

ENSEMBL

ENST00000358432, ENSP00000351209

ZINC - FDA approved

EPHA2_HUMAN

ZINC - Substances

EPHA2_HUMAN

ZINC - Biogenic

EPHA2_HUMAN

ZINC target

P29317

PRO

P29317

GlyGen

P29317

PDB

6FNG, 8TRT, 3HPN, 7KJC, 6HET, 8BOK, 6Q7E, 5NKB, 5NJZ, 8QQY, 8BOM, 5I9W, 3HEI, 5NK5, 6B9L, 2X11, 5NKG, 6F7N, 5IA1, 5NKA, 6NK2, 2E8N, 5NK0, 6FNF, 6NJZ, 7B7N, 8BOD, 8BOG, 5NK3, 5I9V, 5NZ9, 6HES, 3MX0, 5IA5, 6Q7D, 5I9Z, 4TRL, 6HEX, 8BOI, 5NK4, 7CZF, 5NKF, 5IA3, 5NK6, 6Q7C, 6NK1, 8BIO, 3MBW, 6FNH, 8XPV, 7KJA, 3C8X, 8TRS, 5NK2, 5I9U, 8BOH, 6HEV, 5IA2, 2X10, 5NKE, 6Q7G, 5IA4, 5NKI, 4P2K, 8BK0, 6NK0, 7CZE, 3SKJ, 6HEY, 5NK8, 3CZU, 1MQB, 8BOC, 2K9Y, 4PDO, 8BOF, 7KJB, 6RW2, 6HEU, 5NKC, 6HEW, 6Q7F, 5IA0, 5NKD, 6NKP, 5I9X, 8BM8, 5NKH, 5NK9, 3KKA, 5EK7, 5I9Y, 2KSO, 5NK7, 6Q7B, 3FL7, 6F7M, 8T9B, 8BIN, 5NK1

ZINC - Investigational

EPHA2_HUMAN

HPA

ENSG00000142627-EPHA2

Pharos - Targets

P29317

Orphanet

EPHA2

ZINC - Predictions - Purchasable

EPHA2_HUMAN

HMDB Protein

HMDBP01246

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.665	3
UniProt:P29376 LTK	2	p-6Y-LTK [plasma membrane] (R-HSA-9842578) LTK [plasma membrane] (R-HSA-9842564)	0.539	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) SDC1 [Golgi lumen] (R-HSA-2054105) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.499	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.488	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.483	3
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.483	2
UniProt:P29323 EPHB2	6	EPHB2 (?-?) [plasma membrane] (R-HSA-3928394) EPHB2 (?-1055) [cytosol] (R-HSA-3928432) EPHB2 (?-1055) [plasma membrane] (R-HSA-3928386) EPHB2 (19-?) [extracellular region] (R-HSA-3928436) EPHB2 [plasma membrane] (R-HSA-443809) p-Y596,Y602-EPHB2 [plasma membrane] (R-HSA-3928375)	0.483	3
UniProt:P34925 RYK	1	RYK [plasma membrane] (R-HSA-3006746)	0.483	2