Reactome | Recruitment of p190RhoGEF to p-FAK

Recruitment of p190RhoGEF to p-FAK

Stable Identifier

R-HSA-3928598

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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FAK-mediated spine morphogenesis was shown to occur, in part through Rho guanine nucleotide exchange factor 28 (ARHGEF28, p190RhoGEF), suggesting that FAK-mediated spine maturation might proceed through a FAK-RhoGEF-RHOA mechanism. p190RhoGEF binds directly to phosphorylated PTK2 through a motif in the RhoGEF C-terminal domain, a feature not shared with other GEFs (Moeller et al. 2006, Rico et al. 2004, Zhai et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12702722	Direct interaction of focal adhesion kinase with p190RhoGEF Schlaepfer, WW, Cañete-Soler, R, Nie, Z, Wu, J, Zhai, J, Lin, H, Schlaepfer, DD	J. Biol. Chem.	2003
16298995	EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation Moeller, ML, Reichardt, LF, Shi, Y, Ethell, IM	J. Biol. Chem.	2006
15378065	Control of axonal branching and synapse formation by focal adhesion kinase Schmidt, A, Beggs, HE, Reichardt, LF, Schahin-Reed, D, Kimes, N, Rico, B	Nat. Neurosci.	2004