Reactome | SETD8 [nucleoplasm]

SETD8 [nucleoplasm]

Stable Identifier

R-HSA-417142

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase SETD8, SETD8_HUMAN, KMT5A, SET8

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SETD8 methylates TP53 (Homo sapiens)
        
        SETD8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NQR1 KMT5A

Gene Names

KMT5A, PRSET7, SET07, SET8, SETD8

Chain

chain:1-393

Reference Genes

BioGPS Gene:387893 KMT5A

COSMIC (genes):KMT5A KMT5A

CTD Gene:387893 KMT5A

dbSNP Gene:387893 KMT5A

ENSEMBL:ENSG00000183955 KMT5A

ENSEMBL_homo_sapiens_GENE:ENSG00000183955.14 KMT5A

HGNC:29489 KMT5A

KEGG Gene (Homo sapiens):387893 KMT5A

Monarch:387893 KMT5A

NCBI Gene:387893 KMT5A

OMIM:607240 KMT5A

UCSC:Q9NQR1 KMT5A

Reference Transcript

Other Identifiers

11719831_x_at

11719832_x_at

11748042_s_at

11748043_s_at

11748270_s_at

16758585

220200_PM_s_at

220200_s_at

225094_PM_at

225094_at

225118_PM_at

225118_at

2564205

2564206

2564207

2564208

3435824

3435825

3435826

3435827

3435832

3435833

3435836

3435837

3435838

3435839

3435840

3435841

3435842

387893

4038497

4038499

4038500

4038503

4052305

4052306

4052309

4052310

4053790

4053791

4053792

4053793

4053794

4053795

4053798

4053799

48495_at

65649_s_at

77489_at

7959574

8053733

A_14_P108685

A_24_P238855

A_32_P191527

A_32_P82807

GE61385

GE82534

GO:0000122

GO:0000278

GO:0000785

GO:0003714

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005700

GO:0005829

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007049

GO:0007059

GO:0007076

GO:0008168

GO:0016278

GO:0016279

GO:0016740

GO:0018026

GO:0023052

GO:0032259

GO:0036211

GO:0042054

GO:0042799

GO:0043226

GO:0043516

GO:0045892

GO:0051301

GO:0140014

GO:0140096

GO:0140110

GO:0140939

GO:0140944

GO:1901796

GO:2000042

HMNXSV003056635

Hs.111988.2.A1_3p_at

Hs.111988.2.A2_3p_at

ILMN_1651936

PH_hs_0032504

PH_hs_0034350

TC12000985.hg

g9966854_3p_a_at

Inferred To

KMT5A [nucleoplasm] (Sus scrofa)

SETD8 [nucleoplasm] (Bos taurus)

SETD8 [nucleoplasm] (Caenorhabditis elegans)

SETD8 [nucleoplasm] (Danio rerio)

SETD8 [nucleoplasm] (Drosophila melanogaster)

SETD8 [nucleoplasm] (Gallus gallus)

SETD8 [nucleoplasm] (Mus musculus)

SETD8 [nucleoplasm] (Plasmodium falciparum)

SETD8 [nucleoplasm] (Xenopus tropicalis)

Kmt5a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001311433.1, NP_065115.3, NP_001311434.1, NP_001311435.1

Guide to Pharmacology - Targets

2704

OpenTargets

ENSG00000183955

ZINC - Substances

KMT5A_HUMAN

ZINC target

Q9NQR1

PRO

Q9NQR1

PDB

7D1Z, 7XPX, 5W1Y, 5T5G, 5HQ2, 1ZKK, 3F9Z, 3F9Y, 5TEG, 5V2N, 3F9X, 3F9W, 2BQZ, 6BOZ, 7D20, 4IJ8, 5TH7

IntEnz

2.1.1.361

GeneCards

Q9NQR1

HPA

ENSG00000183955-KMT5A

Ensembl

ENSP00000384629, ENST00000402868, ENSG00000183955

Pharos - Targets

Q9NQR1

ZINC - Predictions - Purchasable

KMT5A_HUMAN

HMDB Protein

HMDBP03103

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.775	6
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.632	5
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.564	2