Reactome | NT5E [plasma membrane]

NT5E [plasma membrane]

Stable Identifier

R-HSA-49191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

5'-nucleotidase, ecto (CD73), 5'-nucleotidase precursor, 5'-nucleotidase precursor , Ecto-5'-nucleotidase, 5'-NT, CD73 antigen

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        NT5E:Zn2+ hydrolyses NMN (Homo sapiens)
        
        NT5E:Zn2+ dimer [plasma membrane] (Homo sapiens)
        
        NT5E [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21589 NT5E

Gene Names

NT5E, NT5, NTE

Chain

signal peptide:1-26, chain:27-549, propeptide:550-574

Reference Genes

BioGPS Gene:4907 NT5E

COSMIC (genes):NT5E NT5E

CTD Gene:4907 NT5E

dbSNP Gene:4907 NT5E

ENSEMBL:ENSG00000135318 NT5E

ENSEMBL_homo_sapiens_GENE:ENSG00000135318.12 NT5E

HGNC:8021 NT5E

KEGG Gene (Homo sapiens):4907 NT5E

Monarch:4907 NT5E

NCBI Gene:4907 NT5E

OMIM:129190 NT5E

UCSC:P21589 NT5E

Reference Transcript

Other Identifiers

11719174_a_at

11744681_a_at

11755207_a_at

1553995_PM_a_at

1553995_a_at

17010760

203939_PM_at

203939_at

2915829

2915830

2915845

2915846

2915847

2915851

2915852

2915853

2915854

2915858

2915862

2915866

2915867

2915868

2915869

2915870

2915871

31886_at

4907

74922_at

8120967

89972_at

A_23_P111260

A_24_P316430

A_24_P354715

GE59809

GO:0000166

GO:0002953

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0006196

GO:0006259

GO:0006954

GO:0007155

GO:0007159

GO:0008252

GO:0008253

GO:0008270

GO:0009166

GO:0009897

GO:0009986

GO:0010035

GO:0016020

GO:0016787

GO:0016788

GO:0033198

GO:0042802

GO:0043226

GO:0046032

GO:0046034

GO:0046086

GO:0046872

GO:0050340

GO:0050483

GO:0050484

GO:0050728

GO:0055065

GO:0055074

GO:0055086

GO:0070062

GO:0098552

GO:0106411

GO:0140928

GO:1901135

HMNXSV003037952

Hs2.153952.2.A1_3p_s_at

ILMN_1697220

PH_hs_0009260

TC06000779.hg

X55740_at

g4505466_3p_at

Participates

as a component of

NT5E:Zn2+ dimer [plasma membrane] (Homo sapiens)

Inferred To

NT5E [plasma membrane] (Bos taurus)

NT5E [plasma membrane] (Canis familiaris)

NT5E [plasma membrane] (Gallus gallus)

NT5E [plasma membrane] (Mus musculus)

NT5E [plasma membrane] (Rattus norvegicus)

NT5E [plasma membrane] (Sus scrofa)

nt5e [plasma membrane] (Danio rerio)

nt5e [plasma membrane] (Xenopus tropicalis)

CG1961 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001191742.1, NP_002517.1

Guide to Pharmacology - Targets

1232

OpenTargets

ENSG00000135318

ZINC - Substances

5NTD_HUMAN

ZINC target

P21589

ZINC - Biogenic

5NTD_HUMAN

PRO

P21589

PDB

7P9R, 6Z9D, 6XUE, 6XUG, 7PB5, 4H1S, 6VCA, 7P9T, 6TW0, 6YE1, 6TVX, 7JV8, 7JV9, 4H1Y, 7QGA, 6XUQ, 6YE2, 7PBA, 7PBB, 4H2B, 7PCP, 7PA4, 6S7F, 6TWA, 4H2F, 6TWF, 6HXW, 7QGL, 7BBJ, 7PD9, 6TVE, 7QGM, 7P9N, 6S7H, 4H2G, 4H2I, 7PBY, 6TVG, 7QGO, 6VC9, 6Z9B

IntEnz

3.1.3.89

GeneCards

P21589

HPA

ENSG00000135318-NT5E

Ensembl

ENSP00000358665, ENSG00000135318, ENST00000257770, ENSP00000257770, ENST00000369651

Pharos - Targets

P21589

ZINC - Predictions - Purchasable

5NTD_HUMAN

Orphanet

20750

HMDB Protein

HMDBP00001

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36404 ARL2	2	ARL2 [cytosol] (R-HSA-5216230) ARL2 [mitochondrial matrix] (R-HSA-5250216)	0.527	2
UniProt:Q9Y6B6 SAR1B	3	SAR1B [ER to Golgi transport vesicle membrane] (R-HSA-211498) SAR1B [cytosol] (R-HSA-174678) SAR1B [endoplasmic reticulum membrane] (R-HSA-203995)	0.527	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:P17302 GJA1	6	GJA1 [Golgi membrane] (R-HSA-190649) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [lysosomal membrane] (R-HSA-196173) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [plasma membrane] (R-HSA-158058) GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544)	0.527	2