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K48polyUb-MFN2 [mitochondrial outer membrane]
Stable Identifier
R-HSA-5205668
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-2, MFN2_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
p62 links damaged mitochondria to LC3 (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Homo sapiens)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MFN2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95140 MFN2
Gene Names
MFN2, CPRP1, KIAA0214
Chain
chain:1-757
Reference Genes
BioGPS Gene:9927 MFN2
COSMIC (genes):MFN2 MFN2
CTD Gene:9927 MFN2
dbSNP Gene:9927 MFN2
ENSEMBL:ENSG00000116688 MFN2
HGNC:16877 MFN2
KEGG Gene (Homo sapiens):9927 MFN2
Monarch:9927 MFN2
NCBI Gene:9927 MFN2
OMIM:608507 MFN2
UCSC:O95140 MFN2
Reference Transcript
RefSeq:NM_001127660.1 MFN2
RefSeq:XM_005263547.3 MFN2
RefSeq:NM_014874.3 MFN2
RefSeq:XM_005263548.3 MFN2
RefSeq:XM_005263543.3 MFN2
RefSeq:XM_005263545.3 MFN2
Other Identifiers
0003940167
11739020_a_at
11741010_a_at
11748427_a_at
16659171
201155_s_at
216205_s_at
2320620
2320623
2320625
2320626
2320630
2320632
2320633
2320635
2320636
2320638
2320639
2320641
2320643
2320644
2320645
2320646
2320647
2320648
2320649
2320650
2320651
2320652
2320653
2320654
2320655
2320656
34369_at
7897824
9927
A_14_P132643
A_23_P126135
A_33_P3320277
GE57383
GO:0000166
GO:0001825
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0006605
GO:0006626
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006986
GO:0007005
GO:0007006
GO:0007165
GO:0007596
GO:0008053
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009790
GO:0015031
GO:0015630
GO:0016020
GO:0016021
GO:0016236
GO:0016787
GO:0019899
GO:0022607
GO:0031306
GO:0031625
GO:0034497
GO:0042592
GO:0043167
GO:0043226
GO:0046580
GO:0048593
GO:0048646
GO:0048662
GO:0048856
GO:0051646
GO:0061024
GO:0061734
GO:0120162
GO:1904707
GO:1905461
HMNXSV003052093
Hs.3363.2.S1_3p_a_at
ILMN_1651385
PH_hs_0024267
TC01000152.hg
g7662003_3p_a_at
Participates
as an output of
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
as an input of
p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)
as a component of
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
MFN2 [mitochondrial outer membrane]
Inferred To
MFN2 [mitochondrial outer membrane]
(Bos taurus)
MFN2 [mitochondrial outer membrane]
(Canis familiaris)
MFN2 [mitochondrial outer membrane]
(Gallus gallus)
MFN2 [mitochondrial outer membrane]
(Sus scrofa)
Marf [mitochondrial outer membrane]
(Drosophila melanogaster)
Mfn2 [mitochondrial outer membrane]
(Mus musculus)
Mfn2 [mitochondrial outer membrane]
(Rattus norvegicus)
fzo1 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
K48polyUb-MFN2 [mitochondrial outer membrane]
(Xenopus tropicalis)
Homologues of K48polyUb-MFN2 [mitochondrial outer membrane]
(Drosophila melanogaster)
fzo-1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
fzo [mitochondrial outer membrane]
(Drosophila melanogaster)
mfn2 [mitochondrial outer membrane]
(Danio rerio)
FZO1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005263605.1
,
NP_001121132.1
,
NP_055689.1
,
XP_005263600.1
,
XP_005263604.1
,
XP_005263602.1
Guide to Pharmacology - Targets
3131
OpenTargets
ENSG00000116688
HPA
ENSG00000116688-MFN2
GeneCards
O95140
Ensembl
ENSP00000416338
,
ENST00000444836
,
ENSP00000235329
,
ENSG00000116688
,
ENST00000235329
PRO
O95140
Pharos - Targets
O95140
Orphanet
16394
HMDB Protein
HMDBP08482
PDB
6JFK
,
6JFM
,
6JFL
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PRKN
2
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
PARK2 [cytosol]
(R-HSA-201579)
0.576
4
UniProt:Q8IWA4 MFN1
2
MFN1 [mitochondrial outer membrane]
(R-HSA-992745)
K48polyUb-MFN1 [mitochondrial outer membrane]
(R-HSA-5205679)
0.564
2
UniProt:Q9NX47 MARH5
0.564
2
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
3
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