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MRPS33 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5368228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
28S ribosomal protein S33, mitochondrial, RT33_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial ribosome-associated quality control (Homo sapiens)
55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58) (Homo sapiens)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide (Homo sapiens)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:non-stop mRNA:tRNA:ICT1 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P site:tRNA at E site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)
28S ribosomal subunit:MTIF3 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
MTIF3 binds 28S ribosomal subunit (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit:MTIF3 [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed (Homo sapiens)
55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA (UAA,UAG stop codon):tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPS33 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y291 MRPS33
Gene Names
MRPS33, CGI-139, PTD003
Chain
initiator methionine:1, chain:2-106
Reference Genes
BioGPS Gene:51650 MRPS33
COSMIC (genes):MRPS33 MRPS33
CTD Gene:51650 MRPS33
dbSNP Gene:51650 MRPS33
ENSEMBL:ENSG00000090263 MRPS33
HGNC:16634 MRPS33
KEGG:hsa:51650 MRPS33
Monarch:51650 MRPS33
NCBI Gene:51650 MRPS33
OMIM:611993 MRPS33
UCSC:Q9Y291 MRPS33
Reference Transcript
RefSeq:NM_016071.4 MRPS33
RefSeq:NM_053035.3 MRPS33
Other Identifiers
11733134_a_at
17063656
218654_PM_s_at
218654_s_at
237083_PM_at
237083_at
3076468
3076474
3076476
3076478
3076480
3076482
3076484
3076486
3076488
3076490
3076491
3076492
3076493
3076494
3076495
3076496
3076497
3076498
3076499
3076500
3076501
3076502
3076503
3076504
3076505
3076506
3076525
3076527
3076529
46311_at
51650
59222_at
71649_at
8143433
A_23_P157352
GE475822
GE78947
GE86066
GO:0003735
GO:0005198
GO:0005739
GO:0005743
GO:0005763
GO:0005840
GO:0006412
GO:0032543
GO:1990904
HMNXSV003008437
HMNXSV003051550
Hs.14613.0.A1_3p_at
ILMN_1668397
ILMN_1741264
ILMN_1772722
ILMN_1849146
PH_hs_0004747
PH_hs_0031368
TC07001928.hg
g7706348_3p_a_at
Participates
as a component of
28S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mrps33 [mitochondrial inner membrane]
(Danio rerio)
mRpS33 [mitochondrial inner membrane]
(Drosophila melanogaster)
mrps-33 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Mrps33 [mitochondrial inner membrane]
(Mus musculus)
Mrps33 [mitochondrial inner membrane]
(Rattus norvegicus)
Ghost homologue of MRPS33 [mitochondrial inner membrane]
(Xenopus tropicalis)
MRPS33 [mitochondrial inner membrane]
(Bos taurus)
MRPS33 [mitochondrial inner membrane]
(Canis familiaris)
MRPS33 [mitochondrial inner membrane]
(Gallus gallus)
MRPS33 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
RefSeq
NP_444263.1
,
NP_057155.1
OpenTargets
ENSG00000090263
ENSEMBL
ENSP00000417287
,
ENST00000469351
,
ENST00000393008
,
ENSP00000320567
,
ENST00000496958
,
ENST00000324787
,
ENSG00000090263
,
ENSP00000418451
,
ENSP00000376732
HPA
ENSG00000090263-MRPS33
GeneCards
MRPS33
PRO
Q9Y291
Pharos - Targets
Q9Y291
PDB
6NU3
,
7A5K
,
8CSR
,
8CSP
,
8CSQ
,
7A5I
,
6ZSC
,
8CSU
,
7PNX
,
8OIS
,
6RW5
,
7L08
,
6RW4
,
3J9M
,
7P2E
,
7QI4
,
8QRL
,
6ZM5
,
8QRM
,
7PO1
,
6ZSA
,
6VMI
,
8XT0
,
8RRI
,
6NU2
,
8K2A
,
8CSS
,
6ZS9
,
8CST
,
6ZSD
,
8OIR
,
7A5G
,
7A5F
,
6ZSE
,
7QI5
,
7PNY
,
7PNZ
,
7QI6
,
8QRK
,
8ANY
,
6ZM6
,
8QRN
,
6VLZ
,
6ZSG
,
7PO0
,
6ZSB
,
8XT2
,
7PO2
,
7PO3
,
7OG4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
2
UniProt:Q8IXZ2 ZC3H3
1
ZC3H3 [nucleoplasm]
(R-HSA-9933572)
0.527
3
UniProt:Q07020 RPL18
1
RPL18 [cytosol]
(R-HSA-72420)
0.527
3
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