Reactome | ASPH [endoplasmic reticulum membrane]

ASPH [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5490331

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Aspartyl/asparaginyl beta-hydroxylase, ASPH_HUMAN, junctin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12797 ASPH

Gene Names

ASPH, BAH

Chain

chain:1-758

Reference Genes

BioGPS Gene:444 ASPH

COSMIC (genes):ASPH ASPH

CTD Gene:444 ASPH

dbSNP Gene:444 ASPH

ENSEMBL:ENSG00000198363 ASPH

HGNC:757 ASPH

KEGG:hsa:444 ASPH

Monarch:444 ASPH

NCBI Gene:444 ASPH

OMIM:600582 ASPH

UCSC:Q12797 ASPH

Reference Transcript

Participates

as a component of

RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ASPH [endoplasmic reticulum lumen]

Inferred To

Asph [endoplasmic reticulum membrane] (Mus musculus)

Asph [endoplasmic reticulum membrane] (Rattus norvegicus)

ASPH [endoplasmic reticulum membrane] (Bos taurus)

ASPH [endoplasmic reticulum membrane] (Canis familiaris)

ASPH [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001158227.1, NP_001158223.1, NP_001158228.1, NP_001400831.1, NP_064549.1, NP_001158226.1, NP_115857.1, NP_001158222.1, NP_115856.1, NP_001158225.1, NP_004309.2, NP_115855.1

ENSEMBL

ENSP00000429286, ENSP00000436188, ENST00000517847, ENST00000445642, ENST00000541428, ENSP00000368762, ENSP00000368767, ENST00000379454, ENST00000517903, ENSP00000373856, ENST00000518068, ENSP00000429954, ENSG00000198363, ENST00000356457, ENST00000522603, ENSP00000348841, ENSP00000437864, ENSP00000394013, ENST00000379449, ENSP00000429160, ENST00000389204, ENST00000522835, ENSP00000430245

OpenTargets

ENSG00000198363

GeneCards

ASPH

HPA

ENSG00000198363-ASPH

PRO

Q12797

Pharos - Targets

Q12797

GlyGen

Q12797

Orphanet

ASPH

HMDB Protein

HMDBP01022

PDB

8RE9, 6YYW, 8RE7, 5JZU, 7YBB, 6Z6R, 7YB9, 6Q9F, 6QA5, 7E6J, 7YB8, 8RE8, 6YYV, 8RE5, 8RE6, 5JTC, 6RK9, 5JZA, 5JQY, 5JZ8, 7BMI, 5APA, 7YBA, 6YYX, 6Q9I, 6YYY, 7YBC, 7BMJ, 6Z6Q, 5JZ6, 6YYU

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.643	4
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.643	4
UniProt:Q8NE86 MCU	1	MCU [mitochondrial inner membrane] (R-HSA-8949184)	0.643	4
UniProt:O00186 STXBP3	4	p-Y521-STXBP3 [plasma membrane] (R-HSA-2263472) STXBP3 [plasma membrane] (R-HSA-2263473) p-STXBP3 [cytosol] (R-HSA-114680) STXBP3 [cytosol] (R-HSA-114682)	0.643	4
UniProt:Q9NWR8 MCUB	1	MCUB [mitochondrial inner membrane] (R-HSA-8949153)	0.643	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.643	4
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.527	2
UniProt:Q9BQP7 MGME1	1	MGME1 [mitochondrial matrix] (R-HSA-9915452)	0.527	2
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.527	2
UniProt:Q9H4I9 SMDT1	3	SMDT1 [mitochondrial inner membrane] (R-HSA-8949227) proSMDT1 [mitochondrial inner membrane] (R-HSA-8949655) SMDT1 transit peptide [mitochondrial matrix] (R-HSA-8949642)	0.527	2
UniProt:Q99435 NELL2	1	NELL2 [extracellular region] (R-HSA-9010198)	0.527	2
UniProt:Q9NRW7 VPS45	2	VPS45 [Golgi membrane] (R-HSA-6811025) VPS45 [endosome membrane] (R-HSA-1011607)	0.527	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.482	2

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