Reactome | GNAI3 [plasma membrane]

GNAI3 [plasma membrane]

Stable Identifier

R-HSA-55365

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G(i) alpha-3, Guanine nucleotide-binding protein G(k), alpha subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
      - Gi activation by P2Y purinoceptor 12 (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08754 GNAI3

Gene Names

GNAI3

Chain

initiator methionine:, chain:2-354

Reference Genes

BioGPS Gene:2773 GNAI3

COSMIC (genes):GNAI3 GNAI3

CTD Gene:2773 GNAI3

dbSNP Gene:2773 GNAI3

ENSEMBL:ENSG00000065135 GNAI3

HGNC:4387 GNAI3

KEGG:hsa:2773 GNAI3

Monarch:2773 GNAI3

NCBI Gene:2773 GNAI3

OMIM:139370 GNAI3

UCSC:P08754 GNAI3

Reference Transcript

RefSeq:NM_006496.3 GNAI3

Other Identifiers

11727775_s_at

11727776_at

11727777_at

11727778_a_at

16668272

16668283

16668286

201179_PM_s_at

201179_s_at

201180_PM_s_at

201180_s_at

201181_PM_at

201181_at

2350841

2350842

2350846

2350847

2350848

2350850

2350853

2350854

2350856

2350858

2350859

2350860

2350862

2350864

2350865

2350867

2350869

2350870

2350871

2350873

2350875

2773

3891220

7903703

7903717

84319_at

876_at

A_14_P119691

A_21_P0000999

A_24_P353912

A_33_P3419334

A_33_P3419339

GE79761

GO:0000139

GO:0001664

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005654

GO:0005730

GO:0005737

GO:0005765

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005834

GO:0005856

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0007194

GO:0007212

GO:0016020

GO:0016239

GO:0016787

GO:0019001

GO:0019003

GO:0030496

GO:0031683

GO:0043226

GO:0046039

GO:0046872

GO:0051301

GO:0055086

GO:0070062

GO:1901135

HMNXSV003017600

HMNXSV003023482

HMNXSV003034196

ILMN_1696003

M27543_at

PH_hs_0004215

TC01000947.hg

TC01000948.hg

TC01000949.hg

TC01004606.hg

g183183_3p_a_at

g183224_3p_a_at

g5729849_3p_at

p1100

Participates

as a member of

G alpha (i) [plasma membrane] (Homo sapiens)

Inferred To

Gnai3 [plasma membrane] (Mus musculus)

GNAI3 [plasma membrane] (Bos taurus)

GNAI3 [plasma membrane] (Caenorhabditis elegans)

GNAI3 [plasma membrane] (Canis familiaris)

GNAI3 [plasma membrane] (Danio rerio)

GNAI3 [plasma membrane] (Dictyostelium discoideum)

GNAI3 [plasma membrane] (Drosophila melanogaster)

GNAI3 [plasma membrane] (Gallus gallus)

GNAI3 [plasma membrane] (Saccharomyces cerevisiae)

GNAI3 [plasma membrane] (Schizosaccharomyces pombe)

GNAI3 [plasma membrane] (Sus scrofa)

GNAI3 [plasma membrane] (Xenopus tropicalis)

Guanine nucleotide-binding protein G(k) subunit alpha [plasma membrane] (Rattus norvegicus)

Homologues of GNAI3 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006487.1

ENSEMBL

ENST00000369851, ENSP00000358867, ENSG00000065135

OpenTargets

ENSG00000065135

GeneCards

GNAI3

HPA

ENSG00000065135-GNAI3

ZINC target

P08754

PRO

P08754

Pharos - Targets

P08754

GlyGen

P08754

Orphanet

GNAI3

HMDB Protein

HMDBP11461

PDB

4G5O, 7RA3, 7E9H, 2IHB, 9AVL, 4G5R, 8OY1, 8GVX, 8K9L, 7T11, 4G5S, 7T10, 7KH0, 8SZI, 8SZH, 7X6I, 2ODE, 7RGP, 8JD6, 2V4Z

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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