Reactome | GNAI2 [plasma membrane]

GNAI2 [plasma membrane]

Stable Identifier

R-HSA-55435

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G(i), alpha-2 subunit, Adenylate cyclase-inhibiting G alpha protein

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
      - Gi activation by P2Y purinoceptor 12 (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04899 GNAI2

Gene Names

GNAI2, GNAI2B

Chain

initiator methionine:, chain:2-355

Reference Genes

BioGPS Gene:2771 GNAI2

COSMIC (genes):GNAI2 GNAI2

CTD Gene:2771 GNAI2

dbSNP Gene:2771 GNAI2

ENSEMBL:ENSG00000114353 GNAI2

ENSEMBL_homo_sapiens_GENE:ENSG00000114353.17 GNAI2

HGNC:4385 GNAI2

KEGG Gene (Homo sapiens):2771 GNAI2

Monarch:2771 GNAI2

NCBI Gene:2771 GNAI2

OMIM:139360 GNAI2

UCSC:P04899 GNAI2

Reference Transcript

Other Identifiers

11717889_s_at

11717890_x_at

11746874_a_at

11746875_x_at

11753213_x_at

11757732_x_at

201040_PM_at

201040_at

2622639

2622640

2622643

2622644

2622645

2622648

2622661

2622663

2622665

2622668

2622671

2622672

2622675

2622677

2622685

2622686

2622687

2622688

2622689

2771

37307_at

8079950

A_23_P144113

A_33_P3585268

GE478603

GE525821

GE81109

GO:0000166

GO:0001664

GO:0001973

GO:0003013

GO:0003014

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005834

GO:0005856

GO:0005886

GO:0007049

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007193

GO:0007194

GO:0007213

GO:0007214

GO:0007584

GO:0008283

GO:0008284

GO:0012501

GO:0016020

GO:0016192

GO:0016787

GO:0019001

GO:0023052

GO:0030335

GO:0030425

GO:0030496

GO:0031410

GO:0031683

GO:0032930

GO:0035810

GO:0043226

GO:0044297

GO:0045202

GO:0045955

GO:0046628

GO:0046872

GO:0048870

GO:0050805

GO:0051301

GO:0051924

GO:0070062

GO:0070374

GO:0098992

GO:0140199

GO:1903561

GO:1904707

GO:2000179

GO:2001234

HMNXSV003009251

ILMN_1775762

PH_hs_0004451

PH_hs_0031335

TC03000307.hg

X04828_at

g4504040_3p_at

g4504040_3p_x_at

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Homo sapiens)

as a member of

G alpha (i) [plasma membrane] (Homo sapiens)

Inferred To

GNAI2 [plasma membrane] (Bos taurus)

GNAI2 [plasma membrane] (Canis familiaris)

GNAI2 [plasma membrane] (Dictyostelium discoideum)

GNAI2 [plasma membrane] (Gallus gallus)

GNAI2 [plasma membrane] (Sus scrofa)

GNAZ [plasma membrane] (Saccharomyces cerevisiae)

GNAZ [plasma membrane] (Schizosaccharomyces pombe)

Gnai2 [plasma membrane] (Mus musculus)

gnai2b [plasma membrane] (Danio rerio)

gnai2 [plasma membrane] (Xenopus tropicalis)

G(i), alpha-2 subunit [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001269548.1, NP_001269546.1, NP_001159897.1, NP_002061.1, NP_001269549.1, NP_001269547.1

OpenTargets

ENSG00000114353

GeneCards

P04899

HPA

ENSG00000114353-GNAI2

Ensembl

ENSP00000266027, ENST00000266027, ENSP00000395736, ENST00000451956, ENST00000440628, ENSP00000406871, ENSG00000114353, ENSP00000406369, ENST00000313601, ENSP00000312999, ENST00000422163

PRO

P04899

Pharos - Targets

P04899

Orphanet

25602

HMDB Protein

HMDBP11464

PDB

6D9H, 7YK7, 8THL, 7WVY, 8THK, 7LD3, 7WV9, 7LD4, 7F8V, 7XXI, 7YJ4, 7WVV, 7WVX, 7YK6, 7WVW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32302 CXCR5	1	CXCR5 [plasma membrane] (R-HSA-444505)	0.718	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	13
UniProt:P42866 Oprm1	2	Oprm1 [plasma membrane] (R-MMU-9017924) Oprm1 [plasma membrane] (R-MMU-60951)	0.524	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.483	2

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