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GZMB [cytosol]
Stable Identifier
R-HSA-55915
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Granzyme B, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Granzyme 2, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin 2, Human lymphocyte protein, HLP, C11
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation, myristolyation of BID and translocation to mitochondria (Homo sapiens)
Granzyme-B activates BID by cleavage (Homo sapiens)
GZMB [cytosol] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GZMB cleaves GSDME (Homo sapiens)
GZMB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 intracellular domain regulates transcription (Homo sapiens)
NOTCH2 stimulates GZMB transcription (Homo sapiens)
GZMB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10144 GZMB
Gene Names
GZMB, CGL1, CSPB, CTLA1, GRB
Chain
signal peptide:1-18, propeptide:19-20, chain:21-247
Reference Genes
BioGPS Gene:3002 GZMB
COSMIC (genes):GZMB GZMB
CTD Gene:3002 GZMB
dbSNP Gene:3002 GZMB
ENSEMBL:ENSG00000100453 GZMB
ENSEMBL_homo_sapiens_GENE:ENSG00000100453.14 GZMB
HGNC:4709 GZMB
KEGG Gene (Homo sapiens):3002 GZMB
Monarch:3002 GZMB
NCBI Gene:3002 GZMB
OMIM:123910 GZMB
UCSC:P10144 GZMB
Reference Transcript
RefSeq:NM_004131.5 GZMB
Other Identifiers
11724900_a_at
16791444
210164_PM_at
210164_at
3002
3558366
3558376
3558377
3558378
3558379
3558381
3558386
3558387
3558388
3558394
3558395
37137_at
7978366
A_23_P117602
GE79444
GO:0001772
GO:0002376
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008236
GO:0012501
GO:0016020
GO:0016787
GO:0017148
GO:0023052
GO:0030163
GO:0031640
GO:0042267
GO:0043226
GO:0043231
GO:0044194
GO:0051603
GO:0051604
GO:0070269
GO:0098542
GO:0140096
GO:0140507
HMNXSV003047283
ILMN_2109489
M28879_at
PH_hs_0000138
TC14000982.hg
g338010_3p_at
Participates
as an output of
NOTCH2 stimulates GZMB transcription (Homo sapiens)
Other forms of this molecule
GZMB [cytolytic granule lumen]
Inferred To
Gzmb [cytosol]
(Mus musculus)
Gzmb [cytosol]
(Rattus norvegicus)
GZMB [cytosol]
(Bos taurus)
GZMB [cytosol]
(Canis familiaris)
GZMB [cytosol]
(Gallus gallus)
GZMB [cytosol]
(Sus scrofa)
ctsg [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004122.2
Guide to Pharmacology - Targets
2369
OpenTargets
ENSG00000100453
ZINC - Substances
GRAB_HUMAN
ZINC target
P10144
PRO
P10144
PDB
1FQ3
,
1IAU
IntEnz
3.4.21.79
GeneCards
P10144
HPA
ENSG00000100453-GZMB
Ensembl
ENSP00000216341
,
ENSG00000100453
,
ENST00000216341
Pharos - Targets
P10144
ZINC - Predictions - Purchasable
GRAB_HUMAN
HMDB Protein
HMDBP02728
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10124 SRGN
2
SRGN [extracellular region]
(R-HSA-349747)
SRGN [platelet alpha granule lumen]
(R-HSA-349749)
0.524
2
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