FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)

Stable Identifier
Homo sapiens
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Mitochondrial ferritin (FTMT) is specifically taken up by the mitochondria and processed to a mature protein that assembles into functional ferritin shells. It is a homooligomer of 24 subunits, is roughly spherical and contains a central cavity into which the mineral iron core is deposited. FTMT possesses ferroxidase activity. Iron is taken up in the ferrous form (Fe2+) and deposited as ferric hydroxide (Fe(3+)O(OH)) after oxidation. FTMT may play an important role in the regulation of iron homeostasis in the mitochondrion (Levi et al. 2001, Langlois d'Estaintot et al. 2004).

Literature References
PubMed ID Title Journal Year
11323407 A human mitochondrial ferritin encoded by an intronless gene

Drysdale, J, Bosisio, M, Arosio, P, Levi, S, Sanford, D, Corsi, B, Volz, A, Invernizzi, R

J. Biol. Chem. 2001
15201052 Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala

Santambrogio, P, Précigoux, G, Gallois, B, Arosio, P, Levi, S, Granier, T, Chevalier, JM, Langlois d'Estaintot, B

J. Mol. Biol. 2004
Catalyst Activity

ferroxidase activity of FTMT 24mer [mitochondrial matrix]

Orthologous Events
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