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Presynaptic nicotinic acetylcholine receptors
Stable Identifier
R-HSA-622323
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Acetylcholine binding and downstream events (Homo sapiens)
Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
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Presynaptic acetylcholine receptors are located at or near nerve terminal and modulate the release of neurotransmitter such as glutamate, noradrenaline and dopamine. Activation of presynaptic acetylcholine receptors leads to influx of Ca2+ and sufficient increase in local Ca2+ concentrations which could be due to either direct or indirect Ca2+ entry. Direct Ca2+ entry through acetylcholine receptors containing alpha3 beta4 receptors is sufficient for the release of noradrenaline in hippocampus. Indirect Ca2+ increase could be due to Na+ dependent depolarization and activation of voltage dependent calcium channels (VDCC) as in the case of dopamine release. Local Ca2+ increase could also be due to an initial Ca2+ influx through acetlycholine homomeric receptors containing alpha7 subunits and further increase in Ca2+ is elicited due to Ca2+ induced Ca2+ release (CICR) that involves the ryanodine receptors in the ER and the IP3 receptors. This mechanism is used in hippocampal mossy fibre pathway. Nicotinic acetylcholine receptors may permit both sodium and calcium ions, however, the ratio of sodium and calcium influx makes these receptors either highly sodium permeable or highly calcium permeable.
Literature References
PubMed ID
Title
Journal
Year
9023878
Presynaptic nicotinic ACh receptors
Wonnacott, S
Trends Neurosci
1997
Participants
Events
Highly calcium permeable nicotinic acetylcholine receptors
(Homo sapiens)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
(Homo sapiens)
Participates
as an event of
Acetylcholine binding and downstream events (Homo sapiens)
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
Presynaptic nicotinic acetylcholine receptors (Bos taurus)
Presynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Presynaptic nicotinic acetylcholine receptors (Canis familiaris)
Presynaptic nicotinic acetylcholine receptors (Danio rerio)
Presynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Presynaptic nicotinic acetylcholine receptors (Gallus gallus)
Presynaptic nicotinic acetylcholine receptors (Mus musculus)
Presynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Presynaptic nicotinic acetylcholine receptors (Sus scrofa)
Presynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
Authored
Mahajan, SS (2010-04-01)
Reviewed
Restituito, S (2008-11-27)
Wen, H (2020-01-24)
Created
Mahajan, SS (2010-04-22)
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