Reactome | NDN [nucleoplasm]

NDN [nucleoplasm]

Stable Identifier

R-HSA-6789966

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Necdin, NECD_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
      - Expression of NDN,TP53 (Homo sapiens)
        
        NDN, TP53 [nucleoplasm] (Homo sapiens)
        
        NDN [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99608 NDN

Gene Names

NDN

Chain

chain:1-321

Reference Genes

BioGPS Gene:4692 NDN

COSMIC (genes):NDN NDN

CTD Gene:4692 NDN

dbSNP Gene:4692 NDN

ENSEMBL:ENSG00000182636 NDN

ENSEMBL:ENSG00000182636.8 NDN

HGNC:7675 NDN

KEGG Gene (Homo sapiens):4692 NDN

Monarch:4692 NDN

NCBI Gene:4692 NDN

OMIM:602117 NDN

Reference Transcript

RefSeq:NM_002487.2 NDN

Other Identifiers

11716798_x_at

16806097

209550_PM_at

209550_at

36073_at

3613726

3613727

3613728

3613729

3613730

4692

7986757

ADDON002927.hg

A_23_P106405

GE59105

GO:0000122

GO:0000978

GO:0001228

GO:0001764

GO:0003016

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006325

GO:0006351

GO:0006355

GO:0007409

GO:0007413

GO:0007417

GO:0007585

GO:0008092

GO:0008347

GO:0009791

GO:0019233

GO:0023052

GO:0030154

GO:0030182

GO:0032991

GO:0036211

GO:0042995

GO:0043015

GO:0043204

GO:0043226

GO:0043433

GO:0045944

GO:0048011

GO:0048666

GO:0048675

GO:0048856

GO:0048870

GO:0048871

GO:0050877

GO:0071514

GO:0090312

GO:0140110

GO:1990841

HMNXSV003011031

ILMN_1692058

PH_hs_0003472

TC15001070.hg

U35139_at

g1754970_3p_at

Participates

as a member of

NDN, TP53 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_002478.1

OpenTargets

ENSG00000182636

HPA

ENSG00000182636-NDN

GeneCards

Q99608

Ensembl

ENSG00000182636, ENSP00000497916, ENST00000649030

PRO

Q99608

Pharos - Targets

Q99608

Orphanet

16522

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.666	4
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q13263 TRIM28	2	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.536	2
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.536	2

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