Reactome | UTP18 [nucleoplasm]

UTP18 [nucleoplasm]

Stable Identifier

R-HSA-6790645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U3 small nucleolar RNA-associated protein 18 homolog, UTP18_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y5J1 UTP18

Gene Names

UTP18, WDR50, CDABP0061, CGI-48

Chain

chain:1-556

Reference Genes

BioGPS Gene:51096 UTP18

COSMIC (genes):UTP18 UTP18

CTD Gene:51096 UTP18

dbSNP Gene:51096 UTP18

ENSEMBL:ENSG00000011260 UTP18

HGNC:24274 UTP18

Monarch:51096 UTP18

NCBI Gene:51096 UTP18

OMIM:612816 UTP18

UCSC:Q9Y5J1 UTP18

Reference Transcript

RefSeq:NM_016001.2 UTP18

Other Identifiers

11716868_at

11716869_at

16836156

203721_PM_s_at

203721_s_at

3726995

3726996

3726997

3726998

3726999

3727000

3727001

3727002

3727003

3727004

3727006

3727007

3727008

3727009

3727010

3727011

3727014

3727018

3727019

3727020

3727023

3727024

3727025

3727027

3786973

41824_at

51096

8008530

A_14_P104847

A_23_P130020

GE58644

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006364

GO:0016020

GO:0031965

GO:0032040

GO:0034388

GO:0042274

GO:0043226

HMNXSV003012881

HMNXSV003055631

ILMN_1779584

PH_hs_0021078

TC17000681.hg

g7705764_3p_a_at

Participates

as a component of

UTPB complex [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)

Inferred To

utp18 [nucleoplasm] (Dictyostelium discoideum)

wcd [nucleoplasm] (Drosophila melanogaster)

Utp18 [nucleoplasm] (Mus musculus)

Utp18 [nucleoplasm] (Rattus norvegicus)

UTP18 [nucleoplasm] (Bos taurus)

UTP18 [nucleoplasm] (Caenorhabditis elegans)

UTP18 [nucleoplasm] (Canis familiaris)

UTP18 [nucleoplasm] (Gallus gallus)

UTP18 [nucleoplasm] (Plasmodium falciparum)

UTP18 [nucleoplasm] (Saccharomyces cerevisiae)

UTP18 [nucleoplasm] (Schizosaccharomyces pombe)

UTP18 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000225298, ENST00000225298

OpenTargets

ENSG00000011260

HPA

ENSG00000011260-UTP18

PRO

Q9Y5J1

Pharos - Targets

Q9Y5J1

GlyGen

Q9Y5J1

PDB

7MQ8, 7MQ9, 7MQA

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15269 PWP2	1	PWP2 [nucleoplasm] (R-HSA-6790680)	0.564	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2