Reactome | S100A8 [secretory granule lumen]

S100A8 [secretory granule lumen]

Stable Identifier

R-HSA-6804772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

calgranulin-A, calprotectin L1L subunit, cystic fibrosis antigen

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05109 S100A8

Gene Names

S100A8, CAGA, CFAG, MRP8

Chain

chain:1-93

Reference Genes

BioGPS Gene:6279 S100A8

COSMIC (genes):S100A8 S100A8

CTD Gene:6279 S100A8

dbSNP Gene:6279 S100A8

ENSEMBL:ENSG00000143546 S100A8

ENSEMBL:ENSG00000143546.10 S100A8

HGNC:10498 S100A8

KEGG Gene (Homo sapiens):6279 S100A8

Monarch:6279 S100A8

NCBI Gene:6279 S100A8

OMIM:123885 S100A8

UCSC:P05109 S100A8

Reference Transcript

Other Identifiers

11753823_a_at

16693414

202917_3p_s_at

202917_PM_s_at

202917_s_at

2435993

2435994

2435995

2435997

2436000

2436001

41096_at

6279

7920244

A_23_P434809

GE59677

GO:0002376

GO:0002523

GO:0002544

GO:0002790

GO:0002793

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006914

GO:0006915

GO:0006919

GO:0006935

GO:0006954

GO:0007010

GO:0007155

GO:0008017

GO:0008092

GO:0008270

GO:0008289

GO:0010043

GO:0012501

GO:0014002

GO:0016020

GO:0018119

GO:0023052

GO:0030154

GO:0030307

GO:0030312

GO:0030593

GO:0031012

GO:0031410

GO:0032119

GO:0032496

GO:0034774

GO:0035425

GO:0035662

GO:0036211

GO:0042742

GO:0043226

GO:0045087

GO:0045111

GO:0045471

GO:0046872

GO:0048856

GO:0048870

GO:0050544

GO:0050729

GO:0050786

GO:0050832

GO:0051092

GO:0051493

GO:0055065

GO:0062023

GO:0070062

GO:0070488

GO:0098542

GO:2001244

ILMN_1729801

PH_hs_0019619

TC01003261.hg

g9845519_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

S100A8 [cytosol]

S100A8 [extracellular region]

Inferred To

S100A8 [secretory granule lumen] (Bos taurus)

S100A8 [secretory granule lumen] (Danio rerio)

S100A8 [secretory granule lumen] (Mus musculus)

S100A8 [secretory granule lumen] (Rattus norvegicus)

S100A8 [secretory granule lumen] (Sus scrofa)

S100Z [secretory granule lumen] (Gallus gallus)

Cross References

RefSeq

NP_001306126.1, NP_001306127.1, NP_002955.2, NP_001306130.1

OpenTargets

ENSG00000143546

HPA

ENSG00000143546-S100A8

GeneCards

P05109

Ensembl

ENSP00000357722, ENSP00000357721, ENST00000368733, ENSG00000143546, ENST00000368732

PRO

P05109

Pharos - Targets

P05109

HMDB Protein

HMDBP01887

PDB

4GGF, 5W1F, 7QUV, 6DS2, 4XJK, 1MR8, 1XK4, 5HLV, 5HLO

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	7
UniProt:P35228 NOS2	3	NOS2 [cytosol] (R-HSA-202107) NOS2 [nucleoplasm] (R-HSA-9636250) NOS2 [peroxisomal matrix] (R-HSA-9033124)	0.462	4

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