Reactome | CK2 binds FACT

CK2 binds FACT

Stable Identifier

R-HSA-6805061

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CK2 binds FACT (Homo sapiens)

General

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In response to UV radiation, the casein kinase II (CK2) complex associates with the FACT complex (Keller et al. 2001, Keller and Lu 2002).

Literature References

PubMed ID	Title	Journal	Year
12393879	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex Lu, H, Keller, DM	J. Biol. Chem.	2002
11239457	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 Goodman, R, Shu, H, Lu, H, Zhao, Y, Kapoor, M, Zhang, QH, Keller, DM, Lozano, G, Wang, Y, Zeng, X	Mol. Cell	2001