Reactome | MDH2 [mitochondrial matrix]

MDH2 [mitochondrial matrix]

Stable Identifier

R-HSA-70977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

malate dehydrogenase 2, malate dehydrogenase 2, NAD (mitochondrial), Malate dehydrogenase, mitochondrial precursor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P40926 MDH2

Gene Names

MDH2

Chain

transit peptide:1-24, chain:25-338

Reference Genes

BioGPS Gene:4191 MDH2

COSMIC (genes):MDH2 MDH2

CTD Gene:4191 MDH2

dbSNP Gene:4191 MDH2

ENSEMBL:ENSG00000146701 MDH2

ENSEMBL:ENSG00000146701.12 MDH2

HGNC:6971 MDH2

KEGG Gene (Homo sapiens):4191 MDH2

Monarch:4191 MDH2

NCBI Gene:4191 MDH2

OMIM:154100 MDH2

UCSC:P40926 MDH2

Reference Transcript

Other Identifiers

11747278_a_at

11763335_a_at

17047461

209036_PM_s_at

209036_s_at

213333_PM_at

213333_at

3009300

3009301

3009305

3009307

3009308

3009309

3009310

3009311

3009312

3009314

3009315

3009316

3009317

39001_at

4191

8133690

A_14_P108489

A_23_P31372

A_24_P46808

GE54412

GE61277

GO:0003723

GO:0003824

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005975

GO:0006091

GO:0006094

GO:0006099

GO:0006107

GO:0006108

GO:0006734

GO:0009060

GO:0016020

GO:0016491

GO:0016615

GO:0016616

GO:0019752

GO:0030060

GO:0043226

GO:0043621

GO:0046554

GO:0070062

HMNXSV003012926

HMNXSV003042998

Hs.111076.1.S1_3p_at

ILMN_2079004

PH_hs_0024663

TC07000479.hg

g12804928_3p_a_at

Participates

as a component of

MDH2 dimer [mitochondrial matrix] (Homo sapiens)

Inferred To

MDH2 [mitochondrial matrix] (Bos taurus)

MDH2 [mitochondrial matrix] (Caenorhabditis elegans)

MDH2 [mitochondrial matrix] (Canis familiaris)

MDH2 [mitochondrial matrix] (Danio rerio)

MDH2 [mitochondrial matrix] (Drosophila melanogaster)

MDH2 [mitochondrial matrix] (Gallus gallus)

MDH2 [mitochondrial matrix] (Mus musculus)

MDH2 [mitochondrial matrix] (Plasmodium falciparum)

MDH2 [mitochondrial matrix] (Rattus norvegicus)

MDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

MDH2 [mitochondrial matrix] (Schizosaccharomyces pombe)

MDH2 [mitochondrial matrix] (Sus scrofa)

MDH2 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001269332.1, NP_001269333.1, NP_005909.2

OpenTargets

ENSG00000146701

IntEnz

1.1.1.37

HPA

ENSG00000146701-MDH2

GeneCards

P40926

Ensembl

ENSP00000327070, ENSP00000408649, ENST00000315758, ENSG00000146701, ENST00000432020

ZINC target

P40926

PRO

P40926

Pharos - Targets

P40926

Orphanet

24695

HMDB Protein

HMDBP00858

PDB

4WLV, 4WLO, 4WLE, 4WLN, 4WLU, 2DFD, 4WLF

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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