RNA Polymerase I Transcription Initiation

Stable Identifier
R-HSA-73762
Type
Pathway
Species
Homo sapiens
Compartment
nucleolus
ReviewStatus
5/5
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RNA Polymerase I Transcription Initiation
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During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex.

Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription.

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Events
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as an event of
Event Information
Go Biological Process
transcription initiation at RNA polymerase I promoter (0006361)
Orthologous Events
RNA Polymerase I Transcription Initiation (Bos taurus)
RNA Polymerase I Transcription Initiation (Caenorhabditis elegans)
RNA Polymerase I Transcription Initiation (Canis familiaris)
RNA Polymerase I Transcription Initiation (Dictyostelium discoideum)
RNA Polymerase I Transcription Initiation (Drosophila melanogaster)
RNA Polymerase I Transcription Initiation (Gallus gallus)
RNA Polymerase I Transcription Initiation (Mus musculus)
RNA Polymerase I Transcription Initiation (Rattus norvegicus)
RNA Polymerase I Transcription Initiation (Saccharomyces cerevisiae)
RNA Polymerase I Transcription Initiation (Schizosaccharomyces pombe)
RNA Polymerase I Transcription Initiation (Sus scrofa)
RNA Polymerase I Transcription Initiation (Xenopus tropicalis)
Authored
Comai, L  (2003-07-03)
Created
Comai, L  (2003-07-03)
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