Reactome | TMX3 [platelet alpha granule membrane]

TMX3 [platelet alpha granule membrane]

Stable Identifier

R-HSA-8848889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule membrane

Synonyms

Protein disulfide-isomerase TMX3 ecNumber5.3.4.1/ecNumber, TMX3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96JJ7 TMX3

Gene Names

TMX3, KIAA1830, TXNDC10

Chain

signal peptide:1-24, chain:25-454

Reference Genes

BioGPS Gene:54495 Q96JJ72

COSMIC (genes):TMX3 TMX3

CTD Gene:54495 Q96JJ72

dbSNP Gene:54495 TMX3

ENSEMBL:ENSG00000166479 TMX3

HGNC:24718 Q96JJ72

KEGG:hsa:54495 Q96JJ72

Monarch:54495 Q96JJ72

NCBI Gene:54495 Q96JJ72

OMIM:616102 Q96JJ72

UCSC:Q96JJ7 Q96JJ72

Reference Transcript

Participates

as a member of

Platelet alpha granule membrane components that are released on degranulation [platelet alpha granule membrane] (Homo sapiens)

Other forms of this molecule

TMX3 [plasma membrane]

Inferred To

TMX3 [platelet alpha granule membrane] (Bos taurus)

TMX3 [platelet alpha granule membrane] (Caenorhabditis elegans)

TMX3 [platelet alpha granule membrane] (Canis familiaris)

TMX3 [platelet alpha granule membrane] (Gallus gallus)

TMX3 [platelet alpha granule membrane] (Plasmodium falciparum)

TMX3 [platelet alpha granule membrane] (Schizosaccharomyces pombe)

TMX3 [platelet alpha granule membrane] (Sus scrofa)

tmx3b [platelet alpha granule membrane] (Danio rerio)

Tmx3 [platelet alpha granule membrane] (Drosophila melanogaster)

Tmx3 [platelet alpha granule membrane] (Mus musculus)

Tmx3 [platelet alpha granule membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_061895.3, NP_001337441.1

ENSEMBL

ENST00000562706, ENST00000299608, ENSG00000166479, ENSP00000457262, ENSP00000299608

OpenTargets

ENSG00000166479

IntEnz

5.3.4.1

GeneCards

TMX3

HPA

ENSG00000166479-TMX3

PRO

Q96JJ7

Pharos - Targets

Q96JJ7

GlyGen

Q96JJ7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.527	3
UniProt:O75843 AP1G2	1	AP1G2 [Golgi membrane] (R-HSA-5216197)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	6

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