Reactome | IKK complex recruitment mediated by RIP1

IKK complex recruitment mediated by RIP1

Stable Identifier

R-HSA-937041

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        IKK complex recruitment mediated by RIP1 (Homo sapiens)

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IKK complex recruitment mediated by RIP1

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Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003]

Literature References

PubMed ID	Title	Journal	Year
16115877	Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation Cusson-Hermance, N, Khurana, S, Lee, TH, Fitzgerald, KA, Kelliher, MA	J Biol Chem	2005
16603398	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO Ea, CK, Deng, L, Xia, ZP, Pineda, G, Chen, ZJ	Mol Cell	2006
14530355	Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling Sato, S, Sugiyama, M, Yamamoto, M, Watanabe, Y, Kawai, T, Takeda, K, Akira, S	J. Immunol.	2003