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UBE2D4 [cytosol]
Stable Identifier
R-HSA-947623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin-conjugating enzyme E2 D4, UB2D4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Transfer of ubiquitin from E1 to E2 (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DDX41 ubiquitination by TRIM21 (Homo sapiens)
UBE2D1/2/3/4:ubiquitin [cytosol] (Homo sapiens)
UBE2D1/2/3/4 [cytosol] (Homo sapiens)
UBE2D4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2X8 UBE2D4
Gene Names
UBE2D4, UBCH5D
Chain
chain:1-147
Reference Genes
BioGPS Gene:51619 UBE2D4
COSMIC (genes):UBE2D4 UBE2D4
CTD Gene:51619 UBE2D4
dbSNP Gene:51619 UBE2D4
ENSEMBL:ENSG00000078967 UBE2D4
ENSEMBL_homo_sapiens_GENE:ENSG00000078967.13 UBE2D4
HGNC:21647 UBE2D4
KEGG Gene (Homo sapiens):51619 UBE2D4
Monarch:51619 UBE2D4
NCBI Gene:51619 UBE2D4
UCSC:Q9Y2X8 UBE2D4
Reference Transcript
RefSeq:NM_015983.3 UBE2D4
Other Identifiers
11720114_a_at
17045566
218837_PM_s_at
218837_s_at
221949_PM_at
221949_at
2999641
2999644
2999646
2999648
2999651
2999653
2999661
2999662
2999663
2999665
2999667
2999669
2999671
4826759C_3p_s_at
4866907C_3p_s_at
51619
51774_PM_s_at
51774_s_at
57309_f_at
58900_PM_at
58900_at
62949_at
65521_PM_at
65521_at
8132523
A_23_P374767
A_33_P3637909
GE58637
GE80831
GO:0000151
GO:0000166
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0006511
GO:0016567
GO:0016740
GO:0019787
GO:0030163
GO:0031625
GO:0032446
GO:0035519
GO:0036211
GO:0043226
GO:0044314
GO:0061631
GO:0070534
GO:0070936
GO:0070979
GO:0085020
GO:0140096
HMNXSV003026886
Hs.237946.0.A1_3p_at
ILMN_1707084
PH_hs_0001689
PH_hs_0038169
TC07000268.hg
g8393718_3p_s_at
Participates
as a member of
UBE2D1/2/3/4 [cytosol] (Homo sapiens)
as a candidate of
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
Inferred To
UBE2D1 [cytosol]
(Dictyostelium discoideum)
UBE2D1 [cytosol]
(Plasmodium falciparum)
ube2d4 [cytosol]
(Danio rerio)
ube2d4 [cytosol]
(Xenopus tropicalis)
eff [cytosol]
(Drosophila melanogaster)
UBE2D4 [cytosol]
(Bos taurus)
UBE2D4 [cytosol]
(Sus scrofa)
UBC4 [cytosol]
(Saccharomyces cerevisiae)
let-70 [cytosol]
(Caenorhabditis elegans)
ubc4 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_057067.1
OpenTargets
ENSG00000078967
HPA
ENSG00000078967-UBE2D4
GeneCards
Q9Y2X8
Ensembl
ENST00000222402
,
ENSG00000078967
,
ENSP00000222402
PRO
Q9Y2X8
Pharos - Targets
Q9Y2X8
HMDB Protein
HMDBP11571
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P0P0 RNF181
1
RNF181 [cytoplasm]
(R-HSA-8939317)
0.666
4
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.556
3
UniProt:Q9UHC7 MKRN1
2
MKRN1 [cytosol]
(R-HSA-976042)
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.553
2
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