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K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
Stable Identifier
R-HSA-9707928
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Granulocyte colony-stimulating factor receptor, CSF3R_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Homo sapiens)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Homo sapiens)
CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Homo sapiens)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Homo sapiens)
K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane] (Homo sapiens)
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Homo sapiens)
K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99062 CSF3R
Gene Names
CSF3R, GCSFR
Chain
signal peptide:1-24, chain:25-836
Reference Genes
BioGPS Gene:1441 CSF3R
COSMIC (genes):CSF3R CSF3R
CTD Gene:1441 CSF3R
dbSNP Gene:1441 CSF3R
ENSEMBL:ENSG00000119535 CSF3R
ENSEMBL_homo_sapiens_GENE:ENSG00000119535.20 CSF3R
HGNC:2439 CSF3R
KEGG Gene (Homo sapiens):1441 CSF3R
Monarch:1441 CSF3R
NCBI Gene:1441 CSF3R
OMIM:138971 CSF3R
UCSC:Q99062 CSF3R
Reference Transcript
RefSeq:NM_156039.3 CSF3R
RefSeq:XM_011540748.2 CSF3R
RefSeq:NM_000760.3 CSF3R
RefSeq:NM_172313.2 CSF3R
RefSeq:XM_017000370.1 CSF3R
Other Identifiers
11740932_a_at
11756441_x_at
1441
1553297_PM_a_at
1553297_a_at
16685295
203591_PM_s_at
203591_s_at
2406784
2406785
2406786
2406787
2406788
2406789
2406790
2406791
2406792
2406793
2406794
2406797
2406798
2406801
2406803
2406804
2406805
2406806
2406807
2406808
2406809
2406810
2406811
2406813
2406814
2406816
2406821
2406822
2406825
2406826
34223_at
596_s_at
7914950
A_23_P126218
A_33_P3881262
GE57995
GO:0002376
GO:0004896
GO:0005515
GO:0005576
GO:0005764
GO:0005765
GO:0005773
GO:0005886
GO:0006952
GO:0007155
GO:0007165
GO:0009897
GO:0016020
GO:0019221
GO:0019955
GO:0023052
GO:0030154
GO:0030593
GO:0030666
GO:0031410
GO:0038023
GO:0043226
GO:0043235
GO:0045637
GO:0048856
GO:0048870
GO:0051916
GO:0060089
GO:0097186
HMNXSV003028812
Hs2.2175.4.S1_3p_s_at
ILMN_2323172
ILMN_2371280
M59820_at
PH_hs_0024334
TC01002512.hg
g4503080_3p_a_at
Participates
as a component of
K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
CSF3R [plasma membrane]
p-4Y-CSF3R [plasma membrane]
p-4Y-CSF3R [endocytic vesicle membrane]
K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane]
Inferred To
phospho-CSF3R [lysosomal membrane]
(Bos taurus)
phospho-CSF3R [lysosomal membrane]
(Canis familiaris)
phospho-CSF3R [lysosomal membrane]
(Sus scrofa)
phospho-csf3r [lysosomal membrane]
(Xenopus tropicalis)
Ghost homologue of K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(Drosophila melanogaster)
Ghost homologue of K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(Mus musculus)
Ghost homologue of K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(Rattus norvegicus)
phospho-K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 727
Coordinate
727
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 752
Coordinate
752
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 767
Coordinate
767
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 787
Coordinate
787
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
ubiquitinylated lysine (K48polyUb [lysosomal membrane]) at 655
Coordinate
655
Modification
K48polyUb [lysosomal membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_000751.1
,
XP_016855859.1
,
NP_758519.1
,
XP_011539050.1
,
NP_724781.1
Guide to Pharmacology - Targets
1719
OpenTargets
ENSG00000119535
HPA
ENSG00000119535-CSF3R
GeneCards
Q99062
Ensembl
ENST00000373103
,
ENSP00000362198
,
ENSG00000119535
,
ENST00000373104
,
ENSP00000362196
,
ENST00000373106
,
ENSP00000362195
ZINC target
Q99062
PRO
Q99062
Pharos - Targets
Q99062
Orphanet
17340
PDB
2D9Q
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.524
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.462
4
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