Reactome | UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex

UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex

Stable Identifier

R-HSA-9755507

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex

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VCP (also known as p97) is a hexameric ATPase with known roles in extracting ubiquinated substrates from multimeric E3 ligase complexes to promote their degradation by the 26S proteasome (Richly et al, 2005; Meyer et al, 2000; Rape et al, 2001; Tao et al, 2017; reviewed in van den Boom and Meyer, 2018). VCP has been shown to promote the extraction of ubiquitinated NFE2L2 from the KEAP1:CUL3:RBX1 complex in association with co-factors UBF1 and NPLOC4. UBXN7 also plays a role in the regulation of NFE2L2 protein levels, and interacts with VCP, UBF1 and NPLOC4 (Tao et al, 2017; Di Gregario et al, 2021).

Literature References

PubMed ID	Title	Journal	Year
11733065	Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone Rape, M, Hoppe, T, Gorr, I, Kalocay, M, Richly, H, Jentsch, S	Cell	2001
10811609	A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways Meyer, HH, Shorter, JG, Seemann, J, Pappin, D, Warren, G	EMBO J	2000
29153394	VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling van den Boom, J, Meyer, H	Mol Cell	2018
33444648	UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins Di Gregorio, J, Cilenti, L, Ambivero, CT, Andl, T, Liao, R, Zervos, AS	Biochim Biophys Acta Mol Cell Res	2021
15652483	A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting Richly, H, Rape, M, Braun, S, Rumpf, S, Hoege, C, Jentsch, S	Cell	2005
28115426	p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex Tao, S, Liu, P, Luo, G, Rojo de la Vega, M, Chen, H, Wu, T, Tillotson, J, Chapman, E, Zhang, DD	Mol Cell Biol	2017