Reactome | Regulation of MITF-M-dependent genes involved in apoptosis

Regulation of MITF-M-dependent genes involved in apoptosis

Stable Identifier

R-HSA-9824594

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Regulation of MITF-M-dependent genes involved in apoptosis

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MITF contributes to cellular survival through regulation of anti-apoptotic factors such as BCL2 and BIRC7 (McGill et al, 2002; Dynek et al, 2008; Strub et al, 2011; reviewed in Cheli et al, 2010). Consistent with this, MITF is required for survival of melanoblasts during embryogenesis (Hodgkinson et al, 1993; Opdecamp et al, 1997; Nakayama et al, 1998). MITF may also contribute to survival through regulation of DICER, which in turn regulates expression of a number of genes by virtue of its processing of microRNAs (Levy et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
12086670	Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability Golub, TR, Lin, YL, Jackson, IJ, Fisher, DE, Jordan, SA, Ramaswamy, S, Korsmeyer, SJ, Widlund, HR, Ding, HF, McGill, GG, Horstmann, M, Avery, W, Nishimura, EK, Motyckova, G, Du, J	Cell	2002
8343963	Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein Copeland, NG, Moore, KJ, Hodgkinson, CA, Arnheiter, H, Nakayama, A, Jenkins, NA, Steingrìmsson, E	Cell	1993
9510032	Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently Opdecamp, K, Chen, CC, Hodgkinson, CA, Arnheiter, H, Nguyen, MT, Nakayama, A	Mech Dev	1998
20550935	Lineage-specific transcriptional regulation of DICER by MITF in melanocytes Song, JS, Yokoyama, S, Khaled, M, Chin, L, Robinson, KC, Makino, E, Fisher, DE, Levy, C, Larue, L, Bosenberg, M, Lu, J, Beermann, F, Veguilla, RA, Chen, PH	Cell	2010
21258399	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T	Oncogene	2011
9199364	Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor Opdecamp, K, Pavan, WJ, Hodgkinson, CA, Arnheiter, H, Nguyen, MT, Nakayama, A	Development	1997
19995375	Fifteen-year quest for microphthalmia-associated transcription factor target genes Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R	Pigment Cell Melanoma Res	2010
18451137	Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas Dynek, JN, Zha, J, Fairbrother, WJ, Vucic, D, Liu, J, Chan, SM	Cancer Res	2008