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Smurf2 [nucleoplasm]
Stable Identifier
R-MMU-178202
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
SMURF2, A2A5Z6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
SMURF2 monoubiquitinates SMAD3 (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
Transcriptional regulation by RUNX3 (Mus musculus)
Regulation of RUNX3 expression and activity (Mus musculus)
SMURFs ubiquitinate RUNX3 (Mus musculus)
SMURF [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
SMAD7 binds to SMURF2 (Mus musculus)
SMAD7:SMURF2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
SMURF2 monoubiquitinates SMAD3 (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Mus musculus)
Smurf2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:A2A5Z6 Smurf2
Gene Names
Smurf2
Chain
chain:1-748
Reference Genes
BioGPS Gene:66313 Smurf2
KEGG:mmu:66313 Smurf2
Monarch:66313 Smurf2
NCBI Gene:66313 Smurf2
UCSC:A2A5Z6 Smurf2
Reference Transcript
RefSeq:XM_006533936.4 Smurf2
RefSeq:NM_025481.3 Smurf2
Other Identifiers
10392259
10392261
107970_at
110347_i_at
110348_f_at
114544_at
116070_at
1429045_at
1429046_at
1454894_at
166962_at
17271005
4322344
4363127
4444798
4492002
4522933
4575070
4616331
4628873
4643751
4770347
4795477
4799539
4853097
4863434
4928313
4957504
5060774
5082075
5138708
5169428
5173253
5212784
5213937
5274897
5280682
5315823
5319044
5332466
5333458
5388968
5399624
5423116
5524673
66313
A_52_P472660
A_52_P576886
A_52_P69740
A_55_P1976057
A_55_P2124619
GE1462041
GE40327
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006511
GO:0016020
GO:0016567
GO:0016607
GO:0016740
GO:0030163
GO:0030512
GO:0030514
GO:0042802
GO:0043161
GO:0045121
GO:0046332
GO:0046872
GO:0061630
GO:0140096
GO:1901165
ILMN_2426249
ILMN_2524801
ILMN_3163529
mMC003161
Participates
as a member of
SMURF [nucleoplasm] (Mus musculus)
as an input of
SMAD7 binds to SMURF2 (Mus musculus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
as a component of
SMAD7:SMURF2 [nucleoplasm] (Mus musculus)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Mus musculus)
as an output of
SMURF2 monoubiquitinates SMAD3 (Mus musculus)
Other forms of this molecule
Smurf2 [cytosol]
Inferred From
SMURF2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_079757.2
,
XP_006533999.1
ENSEMBL
ENSMUST00000103067
,
ENSMUST00000092517
,
ENSMUSP00000099356
,
ENSMUSP00000090177
,
ENSMUSG00000018363
PRO
A2A5Z6
MGI
1913563
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
DVL2 [cytosol]
(R-HSA-201694)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.612
8
UniProt:Q9Z101 Pard6a
5
Pard6a [plasma membrane]
(R-MMU-418187)
Pard6a [cytosol]
(R-MMU-420001)
p-S345-Pard6a [cell junction]
(R-MMU-2161131)
Pard6a [cell junction]
(R-MMU-2161135)
phospho-Pard6a [plasma membrane]
(R-MMU-2134533)
0.499
2
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