Reactome | pp-DVL2 [cytosol]

pp-DVL2 [cytosol]

Stable Identifier

R-HSA-3772398

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phospho-Dvl-2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14641 DVL2

Gene Names

DVL2

Chain

chain:1-736

Reference Genes

BioGPS Gene:1856 DVL2

COSMIC (genes):DVL2 DVL2

CTD Gene:1856 DVL2

dbSNP Gene:1856 DVL2

ENSEMBL:ENSG00000004975 DVL2

ENSEMBL_homo_sapiens_GENE:ENSG00000004975.12 DVL2

HGNC:3086 DVL2

KEGG Gene (Homo sapiens):1856 DVL2

Monarch:1856 DVL2

NCBI Gene:1856 DVL2

OMIM:602151 DVL2

UCSC:O14641 DVL2

Reference Transcript

RefSeq:NM_004422.2 DVL2

Other Identifiers

11720199_a_at

11748243_a_at

11749611_a_at

11749612_x_at

16840550

1856

218759_PM_at

218759_at

3743439

3743441

3743442

3743443

3743444

3743445

3743446

3743447

3743448

3743451

3743452

3743453

3743454

3743455

3743456

3743457

3743458

3743459

3743461

3743462

3743463

4851107C_3p_at

57532_PM_at

57532_at

63418_at

8012079

A_23_P55342

GE62651

GO:0001843

GO:0001934

GO:0001947

GO:0003007

GO:0003151

GO:0005109

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0007010

GO:0007379

GO:0007507

GO:0008104

GO:0016020

GO:0016055

GO:0016235

GO:0016328

GO:0016604

GO:0019901

GO:0019904

GO:0022007

GO:0022603

GO:0023052

GO:0030136

GO:0030154

GO:0030674

GO:0031267

GO:0031410

GO:0032956

GO:0035282

GO:0035556

GO:0035567

GO:0036211

GO:0042127

GO:0042802

GO:0043226

GO:0043507

GO:0043621

GO:0045177

GO:0045334

GO:0045944

GO:0046330

GO:0048856

GO:0051091

GO:0060029

GO:0060070

GO:0060071

GO:0060090

GO:0090103

GO:0090179

GO:0150012

HMNXSV003013173

HMNXSV003019168

ILMN_1652163

PH_hs_0031570

TC17001079.hg

g4758215_3p_at

Participates

as a component of

PARD6A:pp-DVL2 [cytosol] (Homo sapiens)

as a member of

Other forms of this molecule

p-DVL2 [cytosol]

p-DVL2 [clathrin-coated endocytic vesicle]

DVL2 [cytosol]

ub-DVL2 [cytosol]

Inferred To

phospho-DVL2 [cytosol] (Bos taurus)

phospho-DVL2 [cytosol] (Canis familiaris)

phospho-DVL2 [cytosol] (Sus scrofa)

phospho-dsh-1 [cytosol] (Caenorhabditis elegans)

phospho-dvl2 [cytosol] (Danio rerio)

phospho-dvl2 [cytosol] (Xenopus tropicalis)

phospho-dsh [cytosol] (Drosophila melanogaster)

Homologues of pp-DVL2 [cytosol] (Caenorhabditis elegans)

phospho-Dvl2 [cytosol] (Mus musculus)

phospho-Dvl2 [cytosol] (Rattus norvegicus)

phospho-mig-5 [cytosol] (Caenorhabditis elegans)

phospho-dsh-2 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_004413.1

OpenTargets

ENSG00000004975

HPA

ENSG00000004975-DVL2

GeneCards

O14641

ZINC target

O14641

Ensembl

ENST00000005340, ENSG00000004975, ENSP00000005340

PRO

O14641

Pharos - Targets

O14641

Orphanet

24497

PDB

3CBY, 5LNP, 5SUZ, 6IW3, 3CBZ, 2REY, 4WIP, 6JCK, 3CBX, 3CC0, 5SUY

Interactors (103)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.778	6
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.745	4
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.675	4
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.668	4
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.646	6
UniProt:P49910 ZN165			0.635	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.632	5
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.623	4
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.621	3
UniProt:Q9Z101 Pard6a	5	Pard6a [plasma membrane] (R-MMU-418187) Pard6a [cytosol] (R-MMU-420001) p-S345-Pard6a [cell junction] (R-MMU-2161131) Pard6a [cell junction] (R-MMU-2161135) phospho-Pard6a [plasma membrane] (R-MMU-2134533)	0.612	6
UniProt:A2A5Z6 Smurf2	2	Smurf2 [cytosol] (R-MMU-5632468) Smurf2 [nucleoplasm] (R-MMU-178202)	0.612	8
UniProt:Q06630 MHR1			0.61	4
UniProt:P57078 RIPK4			0.602	4
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.591	4
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.59	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.564	2
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.564	2
UniProt:Q08909 YO385			0.556	3
UniProt:P39009	2	phospho-p-T68-CHEK2 [nucleoplasm] (R-SCE-113825-2) phospho-p-S,3T-CHEK2 [nucleoplasm] (R-SCE-5683784-2)	0.556	3
UniProt:P17214	2	EST1 [cytosol] (R-SCE-927838) EST1 [cytosol] (R-SCE-927851)	0.556	3
UniProt:P40078 NSA2			0.556	3
UniProt:Q03338 PRP3			0.556	3
UniProt:Q03063 DIG1			0.556	3
UniProt:P53305 RT27			0.556	3
UniProt:Q12181 TAH18	1	TAH18 [cytosol] (R-SCE-2564779)	0.556	3
UniProt:P40087 DDI1			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P40455 YIP2			0.556	3
UniProt:Q12389 DBP10			0.556	3
UniProt:P36084	2	MUD2 [nucleoplasm] (R-SCE-9630011) MUD2 [nucleoplasm] (R-SCE-71987)	0.556	3
UniProt:P25372	2	TRX3 [cytosol] (R-SCE-73668-3) TRX3 [cytosol] (R-SCE-66000-3)	0.556	3
UniProt:Q12439 YO21A			0.556	3
UniProt:P40507 AIR1			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
IntAct:EBI-11522238 CYC2			0.556	3
UniProt:P40956 GTS1			0.556	3
UniProt:P38128	6	phospho-SMP1 [nucleoplasm] (R-SCE-448834) phospho-SMP1 [nucleoplasm] (R-SCE-448838) SMP1 [nucleoplasm] (R-SCE-445325) SMP1 [nucleoplasm] (R-SCE-199903) SMP1 [nucleoplasm] (R-SCE-445328) SMP1 [nucleoplasm] (R-SCE-199938)	0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:P33750 SOF1	2	SOF1 [nucleoplasm] (R-SCE-6790701) SOF1 [nucleoplasm] (R-SCE-6790673)	0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:Q12134 HUA2			0.556	3
UniProt:P38891	2	BAT1 [mitochondrial matrix] (R-SCE-70703) BAT1 [cytosol] (R-SCE-70698)	0.556	3
UniProt:P38339	2	RGD1 [cytosol] (R-SCE-8873920-2) RGD1 [cytosol] (R-SCE-2976016-2)	0.556	3
UniProt:Q12481 RRP36	2	RRP36 [nucleoplasm] (R-SCE-6790697) RRP36 [nucleoplasm] (R-SCE-6790634)	0.556	3
UniProt:Q12083 MLH3			0.556	3
UniProt:P53617 NRD1			0.556	3
UniProt:P05738 RPL9A	1	RPL9A [cytosol] (R-SCE-9633121)	0.556	3
UniProt:P54787	6	VPS9 [cytosol] (R-SCE-8875290) VPS9 [cytosol] (R-SCE-8875419) VPS9 [cytosol] (R-SCE-8875287) VPS9 [cytosol] (R-SCE-8875293) VPS9 [cytosol] (R-SCE-8875292) VPS9 [cytosol] (R-SCE-8871123)	0.556	3
UniProt:P39682 PRP39			0.556	3
UniProt:Q14134 TRIM29	1	TRIM29 [cytosol] (R-HSA-5624343)	0.556	5
UniProt:Q12476 AIR2			0.556	3
UniProt:P48510	2	DSK2 [cytosol] (R-SCE-8866006) DSK2 [cytosol] (R-SCE-8866007)	0.556	3
UniProt:P36575 ARRC			0.553	2
UniProt:Q8IYF1 ELOA2	1	TCEB3B [nucleoplasm] (R-HSA-8867802)	0.553	2
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.553	2
UniProt:Q9NVV9 THAP1			0.553	2
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.553	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.553	2
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.553	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.553	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:Q01167 FOXK2	1	FOXK2 [nucleoplasm] (R-HSA-5689655)	0.527	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.527	3
UniProt:P13727 PRG2	2	PRG2 [extracellular region] (R-HSA-6806492) PRG2 [ficolin-1-rich granule lumen] (R-HSA-6801280)	0.527	2
UniProt:O95897 NOE2			0.527	2
UniProt:Q9HCJ2 LRC4C			0.527	2
UniProt:Q9GZY0 NXF2	2	NXF2 [cytosol] (R-HSA-8932924) NXF2 [nucleoplasm] (R-HSA-8932926)	0.527	2
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.527	2
UniProt:Q5R2U3 Q5R2U3			0.524	2
UniProt:P26368 U2AF2	2	5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011) U2AF2 [nucleoplasm] (R-HSA-71987)	0.519	2
UniProt:Q155Q3 DIXC1			0.499	2
UniProt:Q8N5A5-3 ZGPAT			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.488	2
UniProt:Q96T49 PP16B			0.488	2
UniProt:Q08117-2 TLE5			0.488	3
UniProt:Q9BWG6 SCNM1			0.488	2
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.488	2
UniProt:Q6PJH3 Q6PJH3			0.488	2
UniProt:P19544-6 WT1			0.488	2
UniProt:Q86VK4-3 ZNF410			0.488	2
UniProt:Q8TAP4-4 LMO3			0.488	2
UniProt:O95551 TDP2	1	TDP2 [nucleoplasm] (R-HSA-5687253)	0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:P15622-3 ZNF250			0.488	2
UniProt:Q3B820 F161A			0.488	2
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.488	2
UniProt:Q9P0T4 ZN581			0.488	2
UniProt:Q9H257-2 CARD9			0.488	2
UniProt:Q86YD7 F90A1			0.488	2
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [nucleoplasm] (R-HSA-8952487) DCUN1D1 [cytosol] (R-HSA-8951781)	0.488	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.488	2
UniProt:Q8N7W2-2 BEND7			0.488	2
UniProt:Q9H1M0 N62CL			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.488	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.488	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2

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