Reactome | Tcf7l2 [nucleoplasm]

Tcf7l2 [nucleoplasm]

Stable Identifier

R-MMU-201923

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

TCF7L2, Q924A0

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by VENTX (Mus musculus)
      - VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)
        
        CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (Mus musculus)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Mus musculus)
        
        TCF/LEF [nucleoplasm] (Mus musculus)
        
        Tcf7l2 [nucleoplasm] (Mus musculus)
        
        VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm] (Mus musculus)
        
        TCF/LEF [nucleoplasm] (Mus musculus)
        
        Tcf7l2 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - RUNX3 regulates WNT signaling (Mus musculus)
        
        RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Mus musculus)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
        
        Tcf7l2 [nucleoplasm] (Mus musculus)
        
        RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Mus musculus)
        
        Tcf7l2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q924A0

Gene Names

Tcf7l2

Reference Genes

BioGPS Gene:21416 Tcf7l2

ENSEMBL:ENSMUSG00000024985

ENSEMBL:ENSMUSG00000024985 Tcf7l2

KEGG Gene (Mus musculus):21416 Tcf7l2

Monarch:21416 Tcf7l2

NCBI Gene:21416 Tcf7l2

UCSC:Q924A0 Tcf7l2

Reference Transcript

Other Identifiers

102241_f_at

10464084

114774_at

1425229_a_at

1426639_a_at

1429427_s_at

1429428_at

17360501

21416

4399393

4411707

4501124

4522774

4577786

4664830

4788567

4827952

4910342

4947688

4964545

4992814

5064467

5137550

5167868

5197931

5455467

5493350

5562577

97660_s_at

A_52_P146043

A_52_P316355

A_52_P566741

A_55_P2030160

A_55_P2260094

GE41816

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001568

GO:0001678

GO:0001701

GO:0003676

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0005975

GO:0005977

GO:0006006

GO:0006091

GO:0006111

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006886

GO:0006913

GO:0008013

GO:0008543

GO:0009267

GO:0009749

GO:0009791

GO:0009888

GO:0010867

GO:0010909

GO:0012501

GO:0014003

GO:0016055

GO:0016605

GO:0016922

GO:0019901

GO:0021915

GO:0021983

GO:0022414

GO:0023052

GO:0030154

GO:0030282

GO:0030509

GO:0030514

GO:0030538

GO:0031641

GO:0032024

GO:0032092

GO:0032252

GO:0032350

GO:0032991

GO:0032993

GO:0035019

GO:0035264

GO:0035265

GO:0040037

GO:0042475

GO:0042593

GO:0043065

GO:0043226

GO:0043433

GO:0043565

GO:0043570

GO:0043588

GO:0044334

GO:0045295

GO:0045444

GO:0045599

GO:0045722

GO:0045892

GO:0045893

GO:0045944

GO:0046621

GO:0046827

GO:0046889

GO:0048513

GO:0048557

GO:0048619

GO:0048625

GO:0048641

GO:0048660

GO:0048713

GO:0048856

GO:0050673

GO:0050679

GO:0051897

GO:0060070

GO:0060090

GO:0060325

GO:0061178

GO:0061629

GO:0070016

GO:0070369

GO:0071664

GO:0090090

GO:1901135

GO:1901142

GO:1990907

GO:2000675

GO:2001237

ILMN_1232642

ILMN_1245997

ILMN_2641646

ILMN_2641647

ILMN_3006739

mMC025798

mMR028077

Participates

as a member of

as a candidate of

TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Mus musculus)

Other forms of this molecule

phospho-Tcf7l2 [nucleoplasm]

Inferred From

TCF7L2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001136393.1, NP_001136390.1, NP_001136396.1

Ensembl

ENSMUST00000111646, ENSMUSP00000107273, ENSMUSG00000024985

PRO

Q924A0

MGI

1202879

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02248 Ctnnb1	13	Ctnnb1 [nucleoplasm] (R-MMU-9735212) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) Ctnnb1 [plasma membrane] (R-MMU-9038440)	0.564	5
UniProt:Q9R1Y5	2	Hic1 [nucleoplasm] (R-MMU-4090368) Hic1 [nucleoplasm] (R-MMU-4090364)	0.524	4

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