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phospho-p-Y394-LCK [cytosol]
Stable Identifier
R-MMU-202308
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P06240
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Costimulation by the CD28 family (Mus musculus)
PD-1 signaling (Mus musculus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Change of PKC theta conformation (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Generation of second messenger molecules (Mus musculus)
Phosphorylation of PLC-gamma1 (Mus musculus)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
Activated ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Phosphorylation of SLP-76 (Mus musculus)
Activated ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Phosphorylation of TBSMs in LAT (Mus musculus)
Activated ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
Activation of Lck (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Inactivation of LCK by PTPN22 (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Translocation of ZAP-70 to Immunological synapse (Mus musculus)
Activation of ZAP-70 (Mus musculus)
Activated ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Phosphorylation of ZAP-70 by Lck (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
phospho-p-Y394-LCK [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P06240 Lck
Gene Names
Lck, Lsk-t
Chain
initiator methionine:, chain:2-509
Reference Genes
BioGPS Gene:16818 Lck
ENSEMBL:ENSMUSG00000000409.15 Lck
KEGG Gene (Mus musculus):16818 Lck
Monarch:16818 Lck
NCBI Gene:16818 Lck
UCSC:P06240 Lck
Reference Transcript
RefSeq:NM_001162433.1 Lck
RefSeq:NM_010693.3 Lck
RefSeq:XM_006502818.3 Lck
Other Identifiers
102809_s_at
10516620
1425396_a_at
1439146_s_at
16818
17430413
4365171
4400266
4406208
4558922
4568065
4636803
4683421
4810598
4988917
5290956
5293679
5343788
5394055
5400253
5549197
5565059
A_51_P141288
A_55_P2506985
GE112706
GO:0000166
GO:0000242
GO:0001772
GO:0001784
GO:0002376
GO:0003012
GO:0003823
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0004722
GO:0005102
GO:0005515
GO:0005524
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0006468
GO:0006882
GO:0006919
GO:0007155
GO:0007166
GO:0007169
GO:0009410
GO:0009612
GO:0010038
GO:0010628
GO:0012501
GO:0016004
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0019901
GO:0019903
GO:0023052
GO:0030139
GO:0030154
GO:0030217
GO:0031234
GO:0031410
GO:0034116
GO:0035556
GO:0036211
GO:0038094
GO:0042169
GO:0042492
GO:0042531
GO:0042542
GO:0042608
GO:0042609
GO:0042610
GO:0042802
GO:0043226
GO:0043274
GO:0043548
GO:0044877
GO:0045087
GO:0045121
GO:0045588
GO:0045589
GO:0048856
GO:0050853
GO:0050856
GO:0050870
GO:0051117
GO:0051209
GO:0055065
GO:0055085
GO:0070474
GO:0098542
GO:0098772
GO:0098978
GO:0099091
GO:0140096
GO:1903039
GO:1990405
GO:2001244
ILMN_1224526
ILMN_2651137
mMC001127
x03533_s_at
Participates
as a component of
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-p-Y394-LCK [plasma membrane]
Lck [cytosol]
phospho-p-Y505-LCK [plasma membrane]
LCK [cytosol]
Inferred From
p-Y394-LCK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 394 (in Homo sapiens)
Coordinate
394
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001155905.1
,
NP_034823.1
,
XP_006502881.1
ZINC - Investigational
LCK_MOUSE
ZINC - World Drugs
LCK_MOUSE
IntEnz
2.7.10.2
ZINC - FDA approved
LCK_MOUSE
ZINC - Substances
LCK_MOUSE
Ensembl
ENSMUSP00000066209
,
ENSMUSG00000000409
,
ENSMUST00000102596
,
ENSMUST00000067240
,
ENSMUSP00000099656
ZINC target
P06240
PRO
P06240
MGI
96756
ZINC - Predictions - Purchasable
LCK_MOUSE
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49710 HCLS1
0.704
6
UniProt:P06332
2
Cd4 [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869082)
Cd4 [plasma membrane]
(R-MMU-167542)
0.681
3
UniProt:P27958 POLG
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.656
3
UniProt:P06800
2
PTPRC [secretory granule membrane]
(R-MMU-6806150)
PTPRC [plasma membrane]
(R-MMU-197931)
0.59
2
UniProt:O92972 POLG
0.589
2
UniProt:P01731
1
Cd8a [plasma membrane]
(R-MMU-197601)
0.573
2
UniProt:Q63767
4
phospho-Bcar1 [cytosol]
(R-RNO-372645)
phospho-Bcar1 [cytosol]
(R-RNO-5218739)
phospho-Bcar1 [cytosol]
(R-RNO-8848723)
Bcar1 [cytosol]
(R-RNO-201625)
0.558
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.524
2
UniProt:Q9QXK9
1
Sh2d2a [cytosol]
(R-MMU-4420125)
0.508
3
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