Reactome | Otop1 transports H+ from the extracellular region to the cytosol

Otop1 transports H+ from the extracellular region to the cytosol

Stable Identifier

R-MMU-9729538

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Otop1 transports H+ from the extracellular region to the cytosol

In the presence of extracellular acids, the Otop1 channel passively transports H+ ions along the concentration gradient from the extracellular region to the cytosol (Tu et al. 2018, Teng et al. 2019, Zhang et al. 2019). Otop1 is expressed in type III taste cells where it is responsible for activating depolarization in response to sour (acidic) compounds (Teng et al. 2019, Zhang et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
31543453	Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1 Teng, B, Wilson, CE, Tu, YH, Joshi, NR, Kinnamon, SC, Liman, ER	Curr Biol	2019
31543264	Sour Sensing from the Tongue to the Brain Zhang, J, Jin, H, Zhang, W, Ding, C, O'Keeffe, S, Ye, M, Zuker, CS	Cell	2019
29371428	An evolutionarily conserved gene family encodes proton-selective ion channels Tu, YH, Cooper, AJ, Teng, B, Chang, RB, Artiga, DJ, Turner, HN, Mulhall, EM, Ye, W, Smith, AD, Liman, ER	Science	2018