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phospho-PLCG1 [plasma membrane]
Stable Identifier
R-SSC-167679
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
p-4Y-PLCG1, F1SDV6
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
TCR signaling (Sus scrofa)
Generation of second messenger molecules (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
p-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Translocation of PLC-gamma1 to PIP2 (Sus scrofa)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Innate Immune System (Sus scrofa)
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
p-4Y-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Release of p-PLCG1 (Sus scrofa)
p-4Y-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
p-4Y-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
p-4Y-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
p-4Y-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Role of phospholipids in phagocytosis (Sus scrofa)
Phosphorylation and activation of PLCG (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
p-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Release of PLCG from FCGR (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Sus scrofa)
p-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
p-PLCG [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
Active ALK phosphorylates PLCG1 (Sus scrofa)
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by EGFR (Sus scrofa)
EGFR interacts with phospholipase C-gamma (Sus scrofa)
Active PLC-gamma1 dissociates from EGFR (Sus scrofa)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Downstream signaling of activated FGFR1 (Sus scrofa)
Phospholipase C-mediated cascade: FGFR1 (Sus scrofa)
Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by FGFR4 (Sus scrofa)
Downstream signaling of activated FGFR4 (Sus scrofa)
Phospholipase C-mediated cascade; FGFR4 (Sus scrofa)
Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK2 (TRKB) (Sus scrofa)
Activated NTRK2 signals through PLCG1 (Sus scrofa)
Activated PCLG1 dissociates from NTRK2 (Sus scrofa)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by NTRK3 (TRKC) (Sus scrofa)
Activated NTRK3 signals through PLCG1 (Sus scrofa)
Activated PCLG1 dissociates from NTRK3 (Sus scrofa)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Downstream signal transduction (Sus scrofa)
Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Phosphorylation of PLCgamma by PDGFR (Sus scrofa)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFR2 mediated cell proliferation (Sus scrofa)
PLCG1 disassociates from VEGFR2 and translocate to PM (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
SFKs phosphorylate PLCG1 (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
phospho-PLCG1 [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1SDV6
Gene Names
PLCG1
Reference Genes
ENSEMBL:ENSSSCG00000007356.5
Other Identifiers
100152497
GO:0001701
GO:0001726
GO:0002376
GO:0003824
GO:0004435
GO:0004629
GO:0005168
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0007173
GO:0008180
GO:0010634
GO:0012501
GO:0016477
GO:0016787
GO:0019722
GO:0019901
GO:0023052
GO:0030027
GO:0030971
GO:0032587
GO:0035254
GO:0042995
GO:0043226
GO:0043536
GO:0045766
GO:0048856
GO:0048870
GO:0050804
GO:0050852
GO:0051281
GO:0055065
GO:0055085
GO:0071364
GO:0098685
GO:0098978
GO:1905564
GO:2000353
Ssc.11206.1.A1_at
Participates
as a component of
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
Activated PLC gamma1 bound to PIP2 [plasma membrane] (Sus scrofa)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Sus scrofa)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Sus scrofa)
as a member of
p-4Y-PLCG [plasma membrane] (Sus scrofa)
p-PLCG [plasma membrane] (Sus scrofa)
as an output of
Activated PCLG1 dissociates from NTRK3 (Sus scrofa)
Activated PCLG1 dissociates from NTRK2 (Sus scrofa)
p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)
PLCG1 disassociates from VEGFR2 and translocate to PM (Sus scrofa)
p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)
Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)
Active PLC-gamma1 dissociates from EGFR (Sus scrofa)
Other forms of this molecule
phospho-PLCG1 [plasma membrane]
phospho-PLCG1 [cytosol]
PLCG1 [plasma membrane]
PLCG1 [cytosol]
Inferred From
p-4Y-PLCG1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 472 (in Homo sapiens)
Coordinate
472
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 771 (in Homo sapiens)
Coordinate
771
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 783 (in Homo sapiens)
Coordinate
783
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1253 (in Homo sapiens)
Coordinate
1253
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000124181
Ensembl
ENSSSCP00000007834
,
ENSSSCT00000008048
,
ENSSSCG00000007356
VGNC
96492
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.524
2
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