Reactome | phospho-crfb12 [plasma membrane]

phospho-crfb12 [plasma membrane]

Stable Identifier

R-DRE-873798-9

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

p-Y457-IFNGR1, Q1RM05

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Interferon Signaling (Danio rerio)
    - Interferon gamma signaling (Danio rerio)
      - Binding of STAT1 to p-IFNGR1 (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
      - IFNG signaling activates MAPKs (Danio rerio)
        
        Activated JAK1 binds RAF1 (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        JAK1-activated RAF1 phosphorylates MAPKs (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        JAK1-mediated phosphorylation of RAF1 (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
      - Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
      - Phosphorylation of STAT1 at Ser727 (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
      - Phosphorylation of STAT1 by JAK kinases (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
      - Release of STAT1 dimer from active receptor unit (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)
        
        phospho-crfb12 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q1RM05

Gene Names

crfb12

Reference Genes

BioGPS Gene:678605 crfb12

CTD Gene:678605 crfb12

ENSEMBL:ENSDARG00000052413

KEGG:dre:678605 crfb12

Monarch:678605 crfb12

NCBI Gene:678605 crfb12

UCSC:Q1RM05 crfb12

Reference Transcript

RefSeq:NM_001040353.1 crfb12

Other Identifiers

13208603

678605

A_15_P107691

A_15_P208206

CJ001313

CJ001314

CJ001315

CUST_9289_PI428451958

DRER10065

DRER29801

ENSDART00000074264

ENSDART00000074264_1

ENSDART00000074264_2

GO:0005515

GT_Xhyb_NM_001040353.1_393535

GT_Xhyb_XM_005165557.1_346175

JP001313

JP001314

JP001315

MADDr01003244

NM_001040353

Participates

as a member of

Homologues of p-Y457-IFNGR1 [plasma membrane] (Danio rerio)

Other forms of this molecule

crfb12 [extracellular region]

crfb12 [plasma membrane]

phospho-crfb12 [plasma membrane]

crfb12 [plasma membrane]

phospho-crfb12 [plasma membrane]

crfb12 [plasma membrane]

Inferred From

p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 457 (in Homo sapiens)

Coordinate

457

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001035443.1

ENSEMBL

ENSDART00000074264, ENSDARP00000068753, ENSDARG00000052413

ZFIN

ZDB-GENE-060421-4184

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