Reactome | ANAPC10 [nucleoplasm]

ANAPC10 [nucleoplasm]

Stable Identifier

R-HSA-174047

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apc10/Doc1

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC10 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        ANAPC10 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UM13 ANAPC10

Gene Names

ANAPC10, APC10

Chain

initiator methionine:, chain:2-185

Reference Genes

BioGPS Gene:10393 ANAPC10

COSMIC (genes):ANAPC10 ANAPC10

CTD Gene:10393 ANAPC10

dbSNP Gene:10393 ANAPC10

ENSEMBL:ENSG00000164162 ANAPC10

HGNC:24077 ANAPC10

KEGG:hsa:10393 ANAPC10

Monarch:10393 ANAPC10

NCBI Gene:10393 ANAPC10

OMIM:613745 ANAPC10

UCSC:Q9UM13 ANAPC10

Reference Transcript

Other Identifiers

10393

11735774_a_at

16980291

207845_PM_s_at

207845_s_at

241959_PM_at

241959_at

242777_PM_at

242777_at

2788131

2788132

2788151

2788153

2788154

2788155

2788166

2788173

2788175

2788176

2788179

2788181

2788182

2788183

2788185

2788186

2788187

2788188

2788189

40727_at

70145_at

77087_at

8103005

A_23_P250994

GE544592

GE61948

GO:0005515

GO:0005654

GO:0005680

GO:0005737

GO:0005829

GO:0007346

GO:0016567

GO:0030163

GO:0031145

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0141198

HMNXSV003031683

Hs.127024.0.A1_3p_at

Hs.313860.0.A1_3p_at

ILMN_1770378

ILMN_1849514

PH_hs_0007270

PH_hs_0019536

g7657034_3p_a_at

Participates

as a component of

Other forms of this molecule

ANAPC10 [cytosol]

Inferred To

ANAPC10 [nucleoplasm] (Bos taurus)

ANAPC10 [nucleoplasm] (Canis familiaris)

ANAPC10 [nucleoplasm] (Gallus gallus)

ANAPC10 [nucleoplasm] (Rattus norvegicus)

ANAPC10 [nucleoplasm] (Sus scrofa)

Anapc10 [nucleoplasm] (Mus musculus)

APC10 [nucleoplasm] (Drosophila melanogaster)

anapc10 [nucleoplasm] (Dictyostelium discoideum)

anapc10 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001243636.1, NP_001243637.1, NP_001243638.1, NP_001243639.1, NP_001305296.1, NP_055700.2, XP_011529826.1, NP_001243635.1

OpenTargets

ENSG00000164162

ENSEMBL

ENSP00000310071, ENST00000309439, ENSP00000423995, ENSP00000403891, ENSP00000478501, ENST00000451299, ENSG00000164162, ENST00000507656, ENST00000613466

HPA

ENSG00000164162-ANAPC10

GeneCards

ANAPC10

PRO

Q9UM13

Pharos - Targets

Q9UM13

GlyGen

Q9UM13

PDB

6TM5, 5A31, 5LCW, 6Q6H, 6Q6G, 5KHU, 4UI9, 5L9T, 6TNT, 5L9U, 8TAU, 6TLJ, 8PKP, 8TAR, 5G04, 5G05, 9GAW, 1JHJ, 5KHR

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.621	7

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