Reactome | PAG1 [plasma membrane]

PAG1 [plasma membrane]

Stable Identifier

R-HSA-180500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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External Reference Information

External Reference

UniProt:Q9NWQ8 PAG1

Gene Names

PAG1, CBP, PAG

Chain

chain:1-432

Reference Genes

BioGPS Gene:55824 PAG1

COSMIC (genes):PAG1 PAG1

CTD Gene:55824 PAG1

dbSNP Gene:55824 PAG1

ENSEMBL:ENSG00000076641 PAG1

ENSEMBL_homo_sapiens_GENE:ENSG00000076641.4 PAG1

HGNC:30043 PAG1

KEGG Gene (Homo sapiens):55824 PAG1

Monarch:55824 PAG1

NCBI Gene:55824 PAG1

OMIM:605767 PAG1

UCSC:Q9NWQ8 PAG1

Reference Transcript

Other Identifiers

11724375_at

11724376_at

11724377_at

11724378_s_at

17078558

225622_PM_at

225622_at

225626_PM_at

225626_at

227354_PM_at

227354_at

3142227

3142228

3142229

3142230

3142231

3142232

3142233

3142234

3142235

3142236

3142237

3142238

3142239

3142240

3142241

3142242

3142243

3142244

3142249

3142255

3142256

3142258

3142263

3142266

3142267

3142287

3142299

3142307

3142308

3142309

55824

57670_at

59941_at

61485_at

65068_at

80912_at

8151512

84044_at

A_23_P347070

A_32_P61684

A_33_P3216890

GE82374

GO:0002250

GO:0002376

GO:0005515

GO:0005886

GO:0007155

GO:0007165

GO:0016020

GO:0023052

GO:0035556

GO:0035591

GO:0042169

GO:0045121

GO:0050863

GO:0050868

GO:0060090

HMNXSV003034492

Hs.13256.0.A1_3p_at

Hs.266175.0.S2_3p_at

Hs.266175.0.S3_3p_at

ILMN_1673640

ILMN_1736806

ILMN_2055156

PH_hs_0013669

PH_hs_0037262

TC08001361.hg

Participates

as an output of

Dephosphorylation of PAG by SHP2 (Homo sapiens)

Other forms of this molecule

p-Y317-PAG1 [plasma membrane]

Inferred To

Pag1 [plasma membrane] (Mus musculus)

Pag1 [plasma membrane] (Rattus norvegicus)

PAG1 [plasma membrane] (Bos taurus)

PAG1 [plasma membrane] (Canis familiaris)

PAG1 [plasma membrane] (Gallus gallus)

PAG1 [plasma membrane] (Sus scrofa)

pag1 [plasma membrane] (Danio rerio)

pag1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_016869129.1, XP_016869131.1, XP_016869130.1, NP_060910.3, XP_016869132.1

OpenTargets

ENSG00000076641

GeneCards

Q9NWQ8

HPA

ENSG00000076641-PAG1

Ensembl

ENSP00000220597, ENST00000220597, ENSG00000076641

PRO

Q9NWQ8

Pharos - Targets

Q9NWQ8

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.823	6
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.641	16
UniProt:O14745 NHRF1			0.632	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.623	5
UniProt:P09067 HXB5			0.527	2
UniProt:Q8N6N7 ACBD7	1	ACBD7 [endoplasmic reticulum lumen] (R-HSA-8848238)	0.527	2
UniProt:Q8N5S1 S2541			0.527	2
UniProt:Q9UN70 PCDGK			0.527	2
UniProt:P32246 CCR1	1	CCR1 [plasma membrane] (R-HSA-373107)	0.527	2
UniProt:Q6PEY0 GJB7	1	GJB7 [endoplasmic reticulum membrane] (R-HSA-190639)	0.527	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.499	7

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