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PFN2 [cytosol]
Stable Identifier
R-HSA-3009037
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Profilin-2, PROF2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
SLIT2:ROBO1:Ena/VASP:PFN [plasma membrane] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
Activated FMNL3 binds G-actin (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
RHOC:GTP:FMNL3:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Association of profilin with monomeric actin (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)
CDC42:FMNL2:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Profilin:G-actin binds MKL1 (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
Profilin:G-actin:MKL1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)
Profilin:G-actin:MKL1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
PFN [cytosol] (Homo sapiens)
PFN2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35080 PFN2
Gene Names
PFN2
Chain
initiator methionine:1, chain:2-140
Reference Genes
BioGPS Gene:5217 PFN2
COSMIC - genes:PFN2 PFN2
CTD Gene:5217 PFN2
dbSNP Gene:5217 PFN2
ENSEMBL:ENSG00000070087 PFN2
HGNC:8882 PFN2
KEGG:hsa:5217 PFN2
Monarch:5217 PFN2
NCBI Gene:5217 PFN2
OMIM:176590 PFN2
UCSC:P35080 PFN2
Reference Transcript
RefSeq:NM_053024.4 PFN2
RefSeq:NM_002628.5 PFN2
Other Identifiers
11715701_s_at
11744716_a_at
11753674_a_at
11753675_x_at
16960442
204992_PM_s_at
204992_s_at
2700586
2700587
2700588
2700589
2700590
2700592
2700593
2700594
2700595
2700596
2700597
2700598
2700622
38839_at
38840_s_at
5217
8091446
A_23_P253301
A_24_P396980
GE56374
GO:0003779
GO:0003785
GO:0005515
GO:0005546
GO:0005737
GO:0005856
GO:0008092
GO:0010633
GO:0016020
GO:0016787
GO:0016887
GO:0030036
GO:0030833
GO:0030838
GO:0032233
GO:0033138
GO:0050804
GO:0050821
GO:0051496
GO:0070062
GO:0098685
GO:0098793
GO:0098794
GO:0098885
GO:0098978
GO:0099140
GO:0099171
GO:0110053
GO:1900028
GO:2000300
HMNXSV003045612
HMNXSV003051717
ILMN_1710512
ILMN_1775448
L10678_at
PH_hs_0005096
TC03003145.hg
g4505750_3p_a_at
Participates
as a candidate of
PFN [cytosol] (Homo sapiens)
Inferred To
PFN2 [cytosol]
(Bos taurus)
PFN2 [cytosol]
(Canis familiaris)
PFN2 [cytosol]
(Gallus gallus)
PFN2 [cytosol]
(Sus scrofa)
pfn2 [cytosol]
(Xenopus tropicalis)
Pfn2 [cytosol]
(Mus musculus)
Pfn2 [cytosol]
(Rattus norvegicus)
pfn2a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_002619.1
,
NP_444252.1
ENSEMBL
ENSP00000239940
,
ENSP00000410464
,
ENST00000239940
,
ENSG00000070087
,
ENST00000452853
OpenTargets
ENSG00000070087
GeneCards
PFN2
HPA
ENSG00000070087-PFN2
PRO
P35080
Pharos - Targets
P35080
GlyGen
P35080
PDB
1D1J
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.703
7
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.527
2
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.527
2
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