Reactome | RFFL [nucleoplasm]

RFFL [nucleoplasm]

Stable Identifier

R-HSA-6804433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase rififylin, CARP2, Caspases-8 and -10-associated RING finger protein 2, FYVE-RING finger protein Sakura, Fring, RNF34L, RING finger protein 34-like, RNF189, RING finger protein 189

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)
        
        RNF34,RFFL [nucleoplasm] (Homo sapiens)
        
        RFFL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WZ73 RFFL

Gene Names

RFFL, RNF189, RNF34L

Chain

chain:1-363

Reference Genes

BioGPS Gene:117584 RFFL

COSMIC (genes):RFFL RFFL

CTD Gene:117584 RFFL

dbSNP Gene:117584 RFFL

ENSEMBL:ENSG00000092871 RFFL

ENSEMBL_homo_sapiens_GENE:ENSG00000092871.17 RFFL

HGNC:24821 RFFL

Monarch:117584 RFFL

NCBI Gene:117584 RFFL

OMIM:609735 RFFL

UCSC:Q8WZ73 RFFL

Reference Transcript

RefSeq:NM_001017368.1 RFFL

Other Identifiers

11723116_a_at

117584

11763631_at

1552649_PM_a_at

1552649_a_at

1552651_PM_a_at

1552651_a_at

1562603_PM_at

1562603_at

1566171_PM_at

1566171_at

228980_3p_at

228980_PM_at

228980_at

242155_3p_x_at

242155_PM_x_at

242155_x_at

3753362

3753364

3753366

3753367

3753369

3753371

3753373

3753374

3753375

3753379

3753380

3753381

3753382

3753385

3753386

3753388

3753390

3753398

3753400

3753407

3753408

54832_at

58528_s_at

8014189

A_23_P164089

A_23_P330209

GE512686

GO:0002020

GO:0002039

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006511

GO:0006915

GO:0010008

GO:0010762

GO:0010804

GO:0012501

GO:0016020

GO:0016567

GO:0016740

GO:0019901

GO:0023052

GO:0030163

GO:0031410

GO:0031625

GO:0032006

GO:0036211

GO:0043161

GO:0043226

GO:0046872

GO:0048870

GO:0055038

GO:0061630

GO:0070936

GO:0140096

GO:1901796

GO:1901797

GO:1902042

GO:2001271

HMNXSV003056883

Hs.100754.0.A1_3p_a_at

Hs.100754.0.A1_3p_s_at

Hs.100754.0.A1_3p_x_at

Hs.30724.0.S1_3p_at

Hs.30724.0.S1_3p_s_at

Hs2.172694.1.S1_3p_a_at

Hs2.172694.1.S2_3p_a_at

Hs2.172694.4.S1_3p_at

Hs2.172694.5.S1_3p_at

ILMN_1664111

ILMN_1743356

ILMN_1753819

PH_hs_0026132

TC17002896.hg

p33683

Participates

as a member of

RNF34,RFFL [nucleoplasm] (Homo sapiens)

Inferred To

Rffl [nucleoplasm] (Mus musculus)

Rffl [nucleoplasm] (Rattus norvegicus)

RFFL [nucleoplasm] (Bos taurus)

RFFL [nucleoplasm] (Danio rerio)

RFFL [nucleoplasm] (Sus scrofa)

rffl [nucleoplasm] (Xenopus tropicalis)

dRNF34 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001017368.1

OpenTargets

ENSG00000092871

HPA

ENSG00000092871-RFFL

GeneCards

Q8WZ73

Ensembl

ENSG00000092871, ENST00000413582, ENST00000415395, ENSP00000408513, ENSP00000326170, ENSP00000389832, ENST00000315249, ENST00000447669, ENSP00000412322, ENST00000394597, ENST00000584655, ENSP00000463035, ENSP00000378096

PRO

Q8WZ73

Pharos - Targets

Q8WZ73

PDB

1Y02