Reactome | ZC3H8 [nucleoplasm]

ZC3H8 [nucleoplasm]

Stable Identifier

R-HSA-6807406

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Zinc finger CCCH domain-containing protein 8, ZC3H8_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        LEC [nucleoplasm] (Homo sapiens)
        
        ZC3H8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N5P1 ZC3H8

Gene Names

ZC3H8, ZC3HDC8

Chain

chain:1-291

Reference Genes

BioGPS Gene:84524 ZC3H8

COSMIC (genes):ZC3H8 ZC3H8

CTD Gene:84524 ZC3H8

dbSNP Gene:84524 ZC3H8

ENSEMBL:ENSG00000144161 ZC3H8

ENSEMBL_homo_sapiens_GENE:ENSG00000144161.14 ZC3H8

HGNC:30941 ZC3H8

KEGG Gene (Homo sapiens):84524 ZC3H8

Monarch:84524 ZC3H8

NCBI Gene:84524 ZC3H8

UCSC:Q8N5P1 ZC3H8

Reference Transcript

RefSeq:NM_032494.2 ZC3H8

Other Identifiers

11725781_at

16901894

223506_PM_at

223506_at

239644_PM_at

239644_at

2571219

2571220

2571221

2571222

2571226

2571227

2571228

2571230

2571231

2571232

2571234

2571235

2571236

2571244

2571246

2571247

2571248

46633_at

51700_at

58993_at

8054664

84524

A_23_P108871

GE810270

GE83427

GO:0000122

GO:0000785

GO:0000791

GO:0001162

GO:0001227

GO:0002376

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006915

GO:0007155

GO:0008023

GO:0012501

GO:0015030

GO:0016073

GO:0016604

GO:0030154

GO:0033085

GO:0035363

GO:0042795

GO:0042796

GO:0043029

GO:0043226

GO:0045892

GO:0045945

GO:0046677

GO:0046872

GO:0048856

GO:0070245

GO:0140110

HMNXSV003021807

Hs.34812.0.A1_3p_at

ILMN_1657837

PH_hs_0026868

PH_hs_0038002

TC02002212.hg

g13161144_3p_at

Participates

as a component of

LEC [nucleoplasm] (Homo sapiens)

Inferred To

Zc3h8 [nucleoplasm] (Mus musculus)

Zc3h8 [nucleoplasm] (Rattus norvegicus)

su(sable) [nucleoplasm] (Drosophila melanogaster)

ZC3H8 [nucleoplasm] (Bos taurus)

ZC3H8 [nucleoplasm] (Caenorhabditis elegans)

ZC3H8 [nucleoplasm] (Canis familiaris)

ZC3H8 [nucleoplasm] (Gallus gallus)

ZC3H8 [nucleoplasm] (Sus scrofa)

Ghost homologue of ZC3H8 [nucleoplasm] (Danio rerio)

Ghost homologue of ZC3H8 [nucleoplasm] (Dictyostelium discoideum)

zc3h6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_115883.2

OpenTargets

ENSG00000144161

GeneCards

Q8N5P1

HPA

ENSG00000144161-ZC3H8

Ensembl

ENSP00000386488, ENSG00000144161, ENST00000409573

PRO

Q8N5P1

Pharos - Targets

Q8N5P1

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