G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind to the non-receptor Tyrosine-protein kinase BTK. This binding results in a conformational change in BTK. Subsequently, the structurally modified BTK is released from GNAQ and is now catalytically active. Active BTK can trigger the downstream MAPK p38 pathway. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Bence, K, Ma, W, Kozasa, T, Huang, XY
Ma, YC, Huang, XY
Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH
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