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KCNE3 [plasma membrane]
Stable Identifier
R-HSA-977536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Potassium voltage-gated channel subfamily E member 3, KCNE3_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 2 - plateau phase (Homo sapiens)
AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)
AKAP9:KCNQ1 tetramer:KCNE dimer [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
Phase 3 - rapid repolarisation (Homo sapiens)
AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)
AKAP9:KCNQ1 tetramer:KCNE dimer [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)
Class III antiarrhythmics:KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
KCNH2:KCNE transport K+ from cytosol to extracellular region (Homo sapiens)
Class III antiarrhythmics:KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
KCNH2:KCNE [plasma membrane] (Homo sapiens)
KCNEs [plasma membrane] (Homo sapiens)
KCNE3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6H6 KCNE3
Gene Names
KCNE3
Chain
chain:1-103
Reference Genes
BioGPS Gene:10008 KCNE3
COSMIC - genes:KCNE3 KCNE3
CTD Gene:10008 KCNE3
dbSNP Gene:10008 KCNE3
ENSEMBL:ENSG00000175538 KCNE3
HGNC:6243 KCNE3
KEGG:hsa:10008 KCNE3
Monarch:10008 KCNE3
NCBI Gene:10008 KCNE3
OMIM:604433 KCNE3
UCSC:Q9Y6H6 KCNE3
Reference Transcript
RefSeq:NM_005472.5 KCNE3
RefSeq:XM_054367363.1 KCNE3
RefSeq:XM_047426176.1 KCNE3
RefSeq:XM_017017048.2 KCNE3
RefSeq:XM_054367360.1 KCNE3
RefSeq:XM_017017047.2 KCNE3
RefSeq:XM_017017051.3 KCNE3
RefSeq:XM_047426177.1 KCNE3
RefSeq:XM_054367361.1 KCNE3
RefSeq:XM_054367362.1 KCNE3
RefSeq:XM_054367359.1 KCNE3
RefSeq:XM_017017049.2 KCNE3
Other Identifiers
10008
11720712_a_at
11720713_a_at
11744817_x_at
16742106
222922_PM_at
222922_at
222923_PM_s_at
222923_s_at
227647_PM_at
227647_at
3381966
3381967
3381968
3381969
3381970
3381971
3381973
3381974
3381976
44558_at
57223_at
68984_at
68986_at
7950409
86424_at
A_23_P24948
GE62878
GO:0005249
GO:0005251
GO:0005515
GO:0005737
GO:0005886
GO:0006811
GO:0006813
GO:0006814
GO:0008076
GO:0015459
GO:0016020
GO:0030425
GO:0030644
GO:0031982
GO:0032809
GO:0034220
GO:0042995
GO:0043204
GO:0043226
GO:0043266
GO:0044325
GO:0045121
GO:0055085
GO:0060307
GO:0071805
GO:0086005
GO:0086011
GO:0086091
GO:0097623
GO:0098772
GO:0098915
GO:1902260
GO:1902282
GO:1903765
GO:1905025
GO:1990794
HMNXSV003021426
Hs.30715.1.S1_3p_at
ILMN_1789387
PH_hs_0027006
PH_hs_0028841
TC11002082.hg
g10304441_3p_at
Participates
as a candidate of
KCNEs [plasma membrane] (Homo sapiens)
Inferred To
Kcne3 [plasma membrane]
(Mus musculus)
Kcne3 [plasma membrane]
(Rattus norvegicus)
KCNE3 [plasma membrane]
(Bos taurus)
KCNE3 [plasma membrane]
(Canis familiaris)
KCNE3 [plasma membrane]
(Gallus gallus)
KCNE3 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016872540.1
,
XP_054223336.1
,
XP_054223335.1
,
XP_016872537.1
,
XP_016872536.1
,
XP_054223334.1
,
XP_047282133.1
,
XP_047282132.1
,
XP_016872538.1
,
XP_054223338.1
,
NP_005463.1
,
XP_054223337.1
OpenTargets
ENSG00000175538
ENSEMBL
ENST00000525550
,
ENST00000310128
,
ENSP00000433633
,
ENSP00000310557
,
ENSG00000175538
HPA
ENSG00000175538-KCNE3
GeneCards
KCNE3
PRO
Q9Y6H6
Pharos - Targets
Q9Y6H6
Orphanet
KCNE3
GlyGen
Q9Y6H6
PDB
2NDJ
,
6V00
,
6V01
,
9WD8
HMDB Protein
HMDBP08141
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.527
3
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.527
2
UniProt:O14730 RIOK3
1
RIOK3 [cytosol]
(R-HSA-6791522)
0.527
3
UniProt:Q99650 OSMR
1
OSMR [plasma membrane]
(R-HSA-448654)
0.527
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.527
3
UniProt:Q96HA1 POM121
1
POM121 [nuclear envelope]
(R-HSA-157747)
0.527
2
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.527
2
UniProt:Q6P0N0 MIS18BP1
2
MIS18BP1 [nucleoplasm]
(R-HSA-606300)
p-T653-MIS18BP1 [nucleoplasm]
(R-HSA-9929905)
0.527
2
UniProt:O94887 FARP2
2
p-Y-FARP2 [cytosol]
(R-HSA-9968470)
FARP2 [cytosol]
(R-HSA-396935)
0.527
3
UniProt:Q96MT3 PRICKLE1
2
ub-PRICKLE1 [cytosol]
(R-HSA-4608820)
PRICKLE1 [cytosol]
(R-HSA-4608816)
0.527
3
UniProt:Q6PJF5 RHBDF2
2
iRHOM2 [endoplasmic reticulum membrane]
(R-HSA-9662859)
iRHOM2 [Golgi lumen]
(R-HSA-9673787)
0.527
3
UniProt:Q13332 PTPRS
1
PTPRS [plasma membrane]
(R-HSA-197680)
0.527
3
UniProt:P40818 USP8
2
p-T945-USP8 [cytosol]
(R-HSA-1358714)
USP8 [cytosol]
(R-HSA-917720)
0.527
3
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