Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AKR1C1 [cytosol]
Stable Identifier
R-RNO-2855253-6
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P23457
Locations in the PathwayBrowser
Expand all
Drug ADME (Rattus norvegicus)
Prednisone ADME (Rattus norvegicus)
AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Fatty acid metabolism (Rattus norvegicus)
Arachidonate metabolism (Rattus norvegicus)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Rattus norvegicus)
PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Synthesis of bile acids and bile salts (Rattus norvegicus)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Rattus norvegicus)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Rattus norvegicus)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)
Aldo-keto reductase family [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of fat-soluble vitamins (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
AKRs [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
Retinoid metabolism and transport (Rattus norvegicus)
AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)
AKRs [cytosol] (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
Signaling by Retinoic Acid (Rattus norvegicus)
RA biosynthesis pathway (Rattus norvegicus)
AKR1C3 reduces atRAL to atROL (Rattus norvegicus)
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
AKR1C1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P23457
Reference Genes
BioGPS Gene:191574
ENSEMBL:ENSRNOG00000017672
ENSEMBL:ENSRNOG00055018172
ENSEMBL:ENSRNOG00060015292
ENSEMBL:ENSRNOG00065003556
KEGG:rno:191574
Monarch:191574
NCBI Gene:191574
UCSC:P23457
Reference Transcript
RefSeq:NM_138547.3
Other Identifiers
10799346
1370563_at
1370708_a_at
1396933_s_at
17720519
191574
5633514
5758938
5874171
5923791
6001659
6073802
6232790
6287287
6418795
6467867
6566410
6571990
A_42_P636400
D17310_s_at
GE19476
GO:0016491
GO:0047023
ILMN_1376356
PH_rn_0003554
S35751_f_at
Participates
as a member of
Homologues of AKR1C1 [cytosol] (Rattus norvegicus)
Inferred From
AKR1C1 [cytosol]
(Homo sapiens)
AKR1C2 [cytosol]
(Homo sapiens)
AKR1C3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_612556.1
ENSEMBL
ENSRNOG00000017672
,
ENSRNOT00000023835
,
ENSRNOP00000023835
ZINC - Substances
DIDH_RAT
ZINC target
P23457
PRO
P23457
RGD
708361
PDB
1LWI
,
1RAL
,
1AFS
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text