Reactome | act2 [cytosol]

act2 [cytosol]

Stable Identifier

R-SPO-200811

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

ACTR3, P32390

Locations in the PathwayBrowser

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Immune System (Schizosaccharomyces pombe)

- Innate Immune System (Schizosaccharomyces pombe)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Schizosaccharomyces pombe)
    - Regulation of actin dynamics for phagocytic cup formation (Schizosaccharomyces pombe)
      - Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Schizosaccharomyces pombe)
        
        ARP2/3 complex (ATP bound) [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)
        
        Mother filament:branching complex:daughter filament [cytosol] (Schizosaccharomyces pombe)
        
        ARP2/3 complex (ATP bound) [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)

Signal Transduction (Schizosaccharomyces pombe)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Schizosaccharomyces pombe)
  - Signaling by Rho GTPases (Schizosaccharomyces pombe)
    - RHO GTPase Effectors (Schizosaccharomyces pombe)
      - RHO GTPases Activate WASPs and WAVEs (Schizosaccharomyces pombe)
        
        Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Schizosaccharomyces pombe)
        
        ARP2/3 complex (ATP bound) [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)
        
        Mother filament:branching complex:daughter filament [cytosol] (Schizosaccharomyces pombe)
        
        ARP2/3 complex (ATP bound) [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)

Vesicle-mediated transport (Schizosaccharomyces pombe)

- Membrane Trafficking (Schizosaccharomyces pombe)
  - Clathrin-mediated endocytosis (Schizosaccharomyces pombe)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        ARP2/3 complex [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        ARP2/3 complex [cytosol] (Schizosaccharomyces pombe)
        
        ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)
        
        act2 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P32390

Gene Names

act2

Reference Genes

BioGPS Gene:2543233 act2

ENSEMBL:SPAC630.03

GeneDB:SPAC630.03

KEGG Gene (Schizosaccharomyces pombe):SPAC630.03 act2

Monarch:2543233 act2

NCBI Gene:2543233 act2

Reference Transcript

RefSeq:NM_001018298.2 act2

Participates

as a component of

ACTR3:ATP [cytosol] (Schizosaccharomyces pombe)

Inferred From

ACTR3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_592898.1

PRO

P32390

PDB

8E9B, 6W17, 3DWL, 6W18

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