Reactome | ACTR3 [cytosol]

ACTR3 [cytosol]

Stable Identifier

R-HSA-200811

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ARP3

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        N-WASP binds ARP2/3 and G-actin (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
        
        Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Myosin-Actin filaments [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
        
        Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - Role of myosins in phagosome formation (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Myosin-Actin filaments [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Branching and elongation of mother and daughter filaments (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        ARP2/3 complex [cytosol] (Homo sapiens)
        
        ACTR3:ATP [cytosol] (Homo sapiens)
        
        ACTR3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61158 ACTR3

Gene Names

ACTR3, ARP3

Chain

initiator methionine:, chain:2-418

Reference Genes

BioGPS Gene:10096 ACTR3

COSMIC (genes):ACTR3 ACTR3

CTD Gene:10096 ACTR3

dbSNP Gene:10096 ACTR3

ENSEMBL:ENSG00000115091 ACTR3

HGNC:170 ACTR3

KEGG:hsa:10096 ACTR3

Monarch:10096 ACTR3

NCBI Gene:10096 ACTR3

OMIM:604222 ACTR3

UCSC:P61158 ACTR3

Reference Transcript

RefSeq:NM_005721.4 ACTR3

Other Identifiers

10096

11728643_s_at

11751141_a_at

16884797

200996_PM_at

200996_at

213101_PM_s_at

213101_s_at

213102_PM_at

213102_at

228603_PM_at

228603_at

239170_PM_at

239170_at

2501700

2501701

2501702

2501703

2501704

2501705

2501711

2501714

2501715

2501716

2501717

2501718

2501719

2501721

2501722

2501727

2501728

2501729

2501730

2501731

2501733

2501734

2501735

2501736

2501737

2501738

2501739

2501740

2501741

35271_at

47644_at

54274_at

64157_at

69195_at

8044686

A_14_P104475

A_24_P105771

A_24_P231513

GE58377

GO:0000910

GO:0003779

GO:0005198

GO:0005200

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005885

GO:0005903

GO:0005911

GO:0005925

GO:0006355

GO:0007018

GO:0007163

GO:0008092

GO:0008356

GO:0010592

GO:0015629

GO:0016020

GO:0016344

GO:0022414

GO:0030027

GO:0030030

GO:0033206

GO:0034314

GO:0035861

GO:0042995

GO:0043226

GO:0044782

GO:0045944

GO:0048870

GO:0051015

GO:0051321

GO:0051653

GO:0060271

GO:0070062

GO:0070358

GO:0071346

HMNXSV003015544

HMNXSV003054012

Hs.10927.1.A1_3p_at

Hs.10927.1.A1_3p_s_at

Hs.195789.0.A1_3p_at

Hs.99410.0.A1_3p_at

ILMN_1657153

PH_hs_0020129

TC02000735.hg

g7262289_3p_at

Participates

as a component of

ACTR3:ATP [cytosol] (Homo sapiens)

Inferred To

Arp3 [cytosol] (Drosophila melanogaster)

act2 [cytosol] (Schizosaccharomyces pombe)

actr3 [cytosol] (Danio rerio)

actr3 [cytosol] (Xenopus tropicalis)

ARP3 [cytosol] (Bos taurus)

ARP3 [cytosol] (Saccharomyces cerevisiae)

arx-1 [cytosol] (Caenorhabditis elegans)

arpC [cytosol] (Dictyostelium discoideum)

Actr3 [cytosol] (Mus musculus)

Actr3 [cytosol] (Rattus norvegicus)

ACTR3 [cytosol] (Canis familiaris)

ACTR3 [cytosol] (Gallus gallus)

ACTR3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005712.1

ENSEMBL

ENSP00000263238, ENST00000263238

OpenTargets

ENSG00000115091

HPA

ENSG00000115091-ACTR3

PRO

P61158

Pharos - Targets

P61158

GlyGen

P61158

PDB

6UHC, 8P94, 6YW6, 6YW7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	13
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.491	2

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