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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
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Tissue Distribution
Diseases
Cytomics
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MAL [mitochondrial matrix]
Stable Identifier
R-ALL-113544
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
(S)-Malate, (S)-malic acid, L-Malate, L-Apple acid, L-Malic acid, L-2-Hydroxybutanedioic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
FH tetramer hydrates fumarate to L-malate (Bos taurus)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Bos taurus)
MAL [mitochondrial matrix]
Pyruvate metabolism (Bos taurus)
ME2 tetramer decarboxylates MAL to PYR (Bos taurus)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Bos taurus)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Bos taurus)
MAL [mitochondrial matrix]
Respiratory electron transport (Bos taurus)
Malate-aspartate shuttle (Bos taurus)
MDH2 dimer dehydrogenates MAL (Bos taurus)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Bos taurus)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Bos taurus)
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
Sulfide oxidation to sulfate (Bos taurus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
PC carboxylates PYR to OA (Bos taurus)
MAL [mitochondrial matrix]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Organic anion transporters (Bos taurus)
SLC25A1 exchanges CIT and MAL (Bos taurus)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)
MAL [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
FH tetramer hydrates fumarate to L-malate (Caenorhabditis elegans)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Pyruvate metabolism (Caenorhabditis elegans)
ME2 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Respiratory electron transport (Caenorhabditis elegans)
Malate-aspartate shuttle (Caenorhabditis elegans)
MDH2 dimer dehydrogenates MAL (Caenorhabditis elegans)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Sulfide oxidation to sulfate (Caenorhabditis elegans)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
PC carboxylates PYR to OA (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC25A1 exchanges CIT and MAL (Caenorhabditis elegans)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)
MAL [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
FH tetramer hydrates fumarate to L-malate (Canis familiaris)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Canis familiaris)
MAL [mitochondrial matrix]
Pyruvate metabolism (Canis familiaris)
ME2 tetramer decarboxylates MAL to PYR (Canis familiaris)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Canis familiaris)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Canis familiaris)
MAL [mitochondrial matrix]
Respiratory electron transport (Canis familiaris)
Malate-aspartate shuttle (Canis familiaris)
MDH2 dimer dehydrogenates MAL (Canis familiaris)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Canis familiaris)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Canis familiaris)
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
Sulfide oxidation to sulfate (Canis familiaris)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
PC carboxylates PYR to OA (Canis familiaris)
MAL [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Organic anion transporters (Canis familiaris)
SLC25A1 exchanges CIT and MAL (Canis familiaris)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)
MAL [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
FH tetramer hydrates fumarate to L-malate (Danio rerio)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Danio rerio)
MAL [mitochondrial matrix]
Pyruvate metabolism (Danio rerio)
ME2 tetramer decarboxylates MAL to PYR (Danio rerio)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Danio rerio)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Danio rerio)
MAL [mitochondrial matrix]
Respiratory electron transport (Danio rerio)
Malate-aspartate shuttle (Danio rerio)
MDH2 dimer dehydrogenates MAL (Danio rerio)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Danio rerio)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Danio rerio)
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
Sulfide oxidation to sulfate (Danio rerio)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
PC carboxylates PYR to OA (Danio rerio)
MAL [mitochondrial matrix]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Organic anion transporters (Danio rerio)
SLC25A1 exchanges CIT and MAL (Danio rerio)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Danio rerio)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)
MAL [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
FH tetramer hydrates fumarate to L-malate (Dictyostelium discoideum)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Sulfur amino acid metabolism (Dictyostelium discoideum)
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
Sulfide oxidation to sulfate (Dictyostelium discoideum)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)
MAL [mitochondrial matrix]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Organic anion transporters (Dictyostelium discoideum)
SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)
MAL [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Citric acid cycle (TCA cycle) (Drosophila melanogaster)
FH tetramer hydrates fumarate to L-malate (Drosophila melanogaster)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Drosophila melanogaster)
MAL [mitochondrial matrix]
Pyruvate metabolism (Drosophila melanogaster)
ME2 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Drosophila melanogaster)
MAL [mitochondrial matrix]
Respiratory electron transport (Drosophila melanogaster)
Malate-aspartate shuttle (Drosophila melanogaster)
MDH2 dimer dehydrogenates MAL (Drosophila melanogaster)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Drosophila melanogaster)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Sulfide oxidation to sulfate (Drosophila melanogaster)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
PC carboxylates PYR to OA (Drosophila melanogaster)
MAL [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Organic anion transporters (Drosophila melanogaster)
SLC25A1 exchanges CIT and MAL (Drosophila melanogaster)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)
MAL [mitochondrial matrix]
Metabolism (Gallus gallus)
Carbohydrate metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
MAL [mitochondrial matrix]
malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)
MAL [mitochondrial matrix]
oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)
MAL [mitochondrial matrix]
Lipid metabolism (Gallus gallus)
oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)
MAL [mitochondrial matrix]
The tricarboxylic acid cycle (Gallus gallus)
fumarate + H2O <=> malate (Gallus gallus)
MAL [mitochondrial matrix]
malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)
MAL [mitochondrial matrix]
malate <=> fumarate + H2O (Gallus gallus)
MAL [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Organic anion transporters (Gallus gallus)
SLC25A1 exchanges CIT and MAL (Gallus gallus)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Gallus gallus)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)
MAL [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
FH tetramer hydrates fumarate to L-malate (Homo sapiens)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Homo sapiens)
MAL [mitochondrial matrix]
Pyruvate metabolism (Homo sapiens)
ME2 tetramer decarboxylates MAL to PYR (Homo sapiens)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Homo sapiens)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Homo sapiens)
MAL [mitochondrial matrix]
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
MDH2 dimer dehydrogenates MAL (Homo sapiens)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Homo sapiens)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
Sulfide oxidation to sulfate (Homo sapiens)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
PC carboxylates PYR to OA (Homo sapiens)
MAL [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Organic anion transporters (Homo sapiens)
SLC25A1 exchanges CIT and MAL (Homo sapiens)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)
MAL [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
FH tetramer hydrates fumarate to L-malate (Mus musculus)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Mus musculus)
MAL [mitochondrial matrix]
Pyruvate metabolism (Mus musculus)
ME2 tetramer decarboxylates MAL to PYR (Mus musculus)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Mus musculus)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Mus musculus)
MAL [mitochondrial matrix]
Respiratory electron transport (Mus musculus)
Malate-aspartate shuttle (Mus musculus)
MDH2 dimer dehydrogenates MAL (Mus musculus)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Mus musculus)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Mus musculus)
Sulfur amino acid metabolism (Mus musculus)
Degradation of cysteine and homocysteine (Mus musculus)
Sulfide oxidation to sulfate (Mus musculus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Mus musculus)
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
PC carboxylates PYR to OA (Mus musculus)
MAL [mitochondrial matrix]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Organic anion transporters (Mus musculus)
SLC25A1 exchanges CIT and MAL (Mus musculus)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Mus musculus)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)
MAL [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Citric acid cycle (TCA cycle) (Plasmodium falciparum)
MDH2 dimer dehydrogenates MAL (Plasmodium falciparum)
MAL [mitochondrial matrix]
Respiratory electron transport (Plasmodium falciparum)
Malate-aspartate shuttle (Plasmodium falciparum)
MDH2 dimer dehydrogenates MAL (Plasmodium falciparum)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Plasmodium falciparum)
MAL [mitochondrial matrix]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Organic anion transporters (Plasmodium falciparum)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)
MAL [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
FH tetramer hydrates fumarate to L-malate (Rattus norvegicus)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Rattus norvegicus)
MAL [mitochondrial matrix]
Pyruvate metabolism (Rattus norvegicus)
ME2 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Rattus norvegicus)
MAL [mitochondrial matrix]
Respiratory electron transport (Rattus norvegicus)
Malate-aspartate shuttle (Rattus norvegicus)
MDH2 dimer dehydrogenates MAL (Rattus norvegicus)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Rattus norvegicus)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Sulfur amino acid metabolism (Rattus norvegicus)
Degradation of cysteine and homocysteine (Rattus norvegicus)
Sulfide oxidation to sulfate (Rattus norvegicus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Rattus norvegicus)
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
PC carboxylates PYR to OA (Rattus norvegicus)
MAL [mitochondrial matrix]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Organic anion transporters (Rattus norvegicus)
SLC25A1 exchanges CIT and MAL (Rattus norvegicus)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)
MAL [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Citric acid cycle (TCA cycle) (Saccharomyces cerevisiae)
FH tetramer hydrates fumarate to L-malate (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Pyruvate metabolism (Saccharomyces cerevisiae)
PC carboxylates PYR to OA (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Respiratory electron transport (Saccharomyces cerevisiae)
Malate-aspartate shuttle (Saccharomyces cerevisiae)
MDH2 dimer dehydrogenates MAL (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
Degradation of cysteine and homocysteine (Saccharomyces cerevisiae)
Sulfide oxidation to sulfate (Saccharomyces cerevisiae)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Glucose metabolism (Saccharomyces cerevisiae)
Gluconeogenesis (Saccharomyces cerevisiae)
PC carboxylates PYR to OA (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
Organic anion transporters (Saccharomyces cerevisiae)
SLC25A1 exchanges CIT and MAL (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)
MAL [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Citric acid cycle (TCA cycle) (Schizosaccharomyces pombe)
FH tetramer hydrates fumarate to L-malate (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
Pyruvate metabolism (Schizosaccharomyces pombe)
PC carboxylates PYR to OA (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
Respiratory electron transport (Schizosaccharomyces pombe)
Malate-aspartate shuttle (Schizosaccharomyces pombe)
MDH2 dimer dehydrogenates MAL (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Glucose metabolism (Schizosaccharomyces pombe)
Gluconeogenesis (Schizosaccharomyces pombe)
PC carboxylates PYR to OA (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
Transport of small molecules (Schizosaccharomyces pombe)
SLC-mediated transmembrane transport (Schizosaccharomyces pombe)
Transport of inorganic cations/anions and amino acids/oligopeptides (Schizosaccharomyces pombe)
Organic anion transporters (Schizosaccharomyces pombe)
SLC25A1 exchanges CIT and MAL (Schizosaccharomyces pombe)
MAL [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Citric acid cycle (TCA cycle) (Sus scrofa)
FH tetramer hydrates fumarate to L-malate (Sus scrofa)
MAL [mitochondrial matrix]
MDH2 dimer dehydrogenates MAL (Sus scrofa)
MAL [mitochondrial matrix]
Pyruvate metabolism (Sus scrofa)
ME2 tetramer decarboxylates MAL to PYR (Sus scrofa)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Sus scrofa)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Sus scrofa)
MAL [mitochondrial matrix]
Respiratory electron transport (Sus scrofa)
Malate-aspartate shuttle (Sus scrofa)
MDH2 dimer dehydrogenates MAL (Sus scrofa)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Sus scrofa)
MAL [mitochondrial matrix]
Metabolism of amino acids and derivatives (Sus scrofa)
Sulfur amino acid metabolism (Sus scrofa)
Degradation of cysteine and homocysteine (Sus scrofa)
Sulfide oxidation to sulfate (Sus scrofa)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Sus scrofa)
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
PC carboxylates PYR to OA (Sus scrofa)
MAL [mitochondrial matrix]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Organic anion transporters (Sus scrofa)
SLC25A1 exchanges CIT and MAL (Sus scrofa)
MAL [mitochondrial matrix]
SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)
MAL [mitochondrial matrix]
Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)
MAL [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Citric acid cycle (TCA cycle) (Xenopus tropicalis)
MDH2 dimer dehydrogenates MAL (Xenopus tropicalis)
MAL [mitochondrial matrix]
Pyruvate metabolism (Xenopus tropicalis)
ME2 tetramer decarboxylates MAL to PYR (Xenopus tropicalis)
MAL [mitochondrial matrix]
ME3 tetramer decarboxylates MAL to PYR (Xenopus tropicalis)
MAL [mitochondrial matrix]
PC carboxylates PYR to OA (Xenopus tropicalis)
MAL [mitochondrial matrix]
Respiratory electron transport (Xenopus tropicalis)
Malate-aspartate shuttle (Xenopus tropicalis)
MDH2 dimer dehydrogenates MAL (Xenopus tropicalis)
MAL [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Xenopus tropicalis)
MAL [mitochondrial matrix]
Metabolism of carbohydrates (Xenopus tropicalis)
Glucose metabolism (Xenopus tropicalis)
Gluconeogenesis (Xenopus tropicalis)
PC carboxylates PYR to OA (Xenopus tropicalis)
MAL [mitochondrial matrix]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Organic anion transporters (Xenopus tropicalis)
SLC25A1 exchanges CIT and MAL (Xenopus tropicalis)
MAL [mitochondrial matrix]
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)
MAL [mitochondrial matrix]
External Reference Information
External Reference
(S)-malate(2-) [ChEBI:15589]
Participates
as an input of
malate <=> fumarate + H2O (Gallus gallus)
malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)
malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)
SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)
SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)
SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
SLC25A10 mediates exchange of malate and phosphate (Drosophila melanogaster)
SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)
SLC25A10 mediates exchange of malate and phosphate (Danio rerio)
SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)
SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)
SLC25A10 mediates exchange of malate and phosphate (Rattus norvegicus)
SLC25A10 mediates exchange of malate and phosphate (Mus musculus)
SLC25A10 mediates exchange of malate and phosphate (Homo sapiens)
MDH2 dimer dehydrogenates MAL (Xenopus tropicalis)
ME3 tetramer decarboxylates MAL to PYR (Xenopus tropicalis)
ME2 tetramer decarboxylates MAL to PYR (Xenopus tropicalis)
MDH2 dimer dehydrogenates MAL (Plasmodium falciparum)
MDH2 dimer dehydrogenates MAL (Saccharomyces cerevisiae)
ME2 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
ME3 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)
MDH2 dimer dehydrogenates MAL (Schizosaccharomyces pombe)
ME3 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
MDH2 dimer dehydrogenates MAL (Caenorhabditis elegans)
ME2 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)
ME3 tetramer decarboxylates MAL to PYR (Gallus gallus)
MDH2 dimer dehydrogenates MAL (Drosophila melanogaster)
MDH2 dimer dehydrogenates MAL (Gallus gallus)
ME3 tetramer decarboxylates MAL to PYR (Danio rerio)
MDH2 dimer dehydrogenates MAL (Danio rerio)
ME2 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
MDH2 dimer dehydrogenates MAL (Rattus norvegicus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Gallus gallus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)
ME3 tetramer decarboxylates MAL to PYR (Canis familiaris)
MDH2 dimer dehydrogenates MAL (Canis familiaris)
MDH2 dimer dehydrogenates MAL (Homo sapiens)
ME3 tetramer decarboxylates MAL to PYR (Bos taurus)
MDH2 dimer dehydrogenates MAL (Bos taurus)
MDH2 dimer dehydrogenates MAL (Mus musculus)
MDH2 dimer dehydrogenates MAL (Sus scrofa)
ME3 tetramer decarboxylates MAL to PYR (Mus musculus)
ME3 tetramer decarboxylates MAL to PYR (Homo sapiens)
ME3 tetramer decarboxylates MAL to PYR (Rattus norvegicus)
ME3 tetramer decarboxylates MAL to PYR (Sus scrofa)
ME2 tetramer decarboxylates MAL to PYR (Homo sapiens)
ME2 tetramer decarboxylates MAL to PYR (Mus musculus)
ME2 tetramer decarboxylates MAL to PYR (Canis familiaris)
ME2 tetramer decarboxylates MAL to PYR (Bos taurus)
ME2 tetramer decarboxylates MAL to PYR (Sus scrofa)
ME2 tetramer decarboxylates MAL to PYR (Danio rerio)
as an output of
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)
fumarate + H2O <=> malate (Gallus gallus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Saccharomyces cerevisiae)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Dictyostelium discoideum)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Drosophila melanogaster)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Sus scrofa)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Canis familiaris)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Mus musculus)
Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)
SLC25A1 exchanges CIT and MAL (Saccharomyces cerevisiae)
SLC25A1 exchanges CIT and MAL (Schizosaccharomyces pombe)
SLC25A1 exchanges CIT and MAL (Caenorhabditis elegans)
SLC25A1 exchanges CIT and MAL (Drosophila melanogaster)
SLC25A1 exchanges CIT and MAL (Gallus gallus)
SLC25A1 exchanges CIT and MAL (Xenopus tropicalis)
SLC25A1 exchanges CIT and MAL (Danio rerio)
SLC25A1 exchanges CIT and MAL (Sus scrofa)
SLC25A1 exchanges CIT and MAL (Bos taurus)
SLC25A1 exchanges CIT and MAL (Canis familiaris)
SLC25A1 exchanges CIT and MAL (Rattus norvegicus)
SLC25A1 exchanges CIT and MAL (Mus musculus)
SLC25A1 exchanges CIT and MAL (Homo sapiens)
FH tetramer hydrates fumarate to L-malate (Dictyostelium discoideum)
SLC25A11 exchanges 2-OG and MAL (Xenopus tropicalis)
SLC25A11 exchanges 2-OG and MAL (Plasmodium falciparum)
FH tetramer hydrates fumarate to L-malate (Saccharomyces cerevisiae)
FH tetramer hydrates fumarate to L-malate (Schizosaccharomyces pombe)
SLC25A11 exchanges 2-OG and MAL (Caenorhabditis elegans)
FH tetramer hydrates fumarate to L-malate (Caenorhabditis elegans)
SLC25A11 exchanges 2-OG and MAL (Drosophila melanogaster)
FH tetramer hydrates fumarate to L-malate (Drosophila melanogaster)
SLC25A11 exchanges 2-OG and MAL (Gallus gallus)
FH tetramer hydrates fumarate to L-malate (Gallus gallus)
SLC25A11 exchanges 2-OG and MAL (Danio rerio)
FH tetramer hydrates fumarate to L-malate (Danio rerio)
SLC25A11 exchanges 2-OG and MAL (Mus musculus)
FH tetramer hydrates fumarate to L-malate (Rattus norvegicus)
SLC25A11 exchanges 2-OG and MAL (Rattus norvegicus)
SLC25A11 exchanges 2-OG and MAL (Homo sapiens)
SLC25A11 exchanges 2-OG and MAL (Canis familiaris)
FH tetramer hydrates fumarate to L-malate (Canis familiaris)
FH tetramer hydrates fumarate to L-malate (Homo sapiens)
FH tetramer hydrates fumarate to L-malate (Bos taurus)
SLC25A11 exchanges 2-OG and MAL (Bos taurus)
FH tetramer hydrates fumarate to L-malate (Mus musculus)
SLC25A11 exchanges 2-OG and MAL (Sus scrofa)
FH tetramer hydrates fumarate to L-malate (Sus scrofa)
This entity regulates
Negatively
PC carboxylates PYR to OA
(Saccharomyces cerevisiae)
PC carboxylates PYR to OA
(Schizosaccharomyces pombe)
PC carboxylates PYR to OA
(Caenorhabditis elegans)
PC carboxylates PYR to OA
(Drosophila melanogaster)
PC carboxylates PYR to OA
(Danio rerio)
PC carboxylates PYR to OA
(Xenopus tropicalis)
PC carboxylates PYR to OA
(Mus musculus)
PC carboxylates PYR to OA
(Sus scrofa)
PC carboxylates PYR to OA
(Bos taurus)
PC carboxylates PYR to OA
(Canis familiaris)
PC carboxylates PYR to OA
(Rattus norvegicus)
PC carboxylates PYR to OA
(Homo sapiens)
Other forms of this molecule
MAL [cytosol]
Cross References
AraCyc
MAL
CAS
97-67-6
,
6915-15-7
COMPOUND
C00149
PubChem Compound
5459792
ZINC
000000895074
KEGG Gene
C00149
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