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PI3K Cascade
Stable Identifier
R-HSA-109704
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
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High
|
PPTX
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SBGN
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The PI3K (Phosphatidlyinositol-3-kinase) - AKT signaling pathway stimulates cell growth and survival.
Literature References
PubMed ID
Title
Journal
Year
15209377
PI 3-kinase, Akt and cell survival
Downward, J
Semin. Cell Dev. Biol.
2004
Participants
Events
PI3K-containing complexes phosphorylate PIP2 to PIP3
(Homo sapiens)
Activation of AKT2
(Homo sapiens)
PKB-mediated events
(Homo sapiens)
Participates
as an event of
IRS-mediated signalling (Homo sapiens)
Orthologous Events
PI3K Cascade (Bos taurus)
PI3K Cascade (Caenorhabditis elegans)
PI3K Cascade (Canis familiaris)
PI3K Cascade (Danio rerio)
PI3K Cascade (Dictyostelium discoideum)
PI3K Cascade (Drosophila melanogaster)
PI3K Cascade (Gallus gallus)
PI3K Cascade (Mus musculus)
PI3K Cascade (Plasmodium falciparum)
PI3K Cascade (Rattus norvegicus)
PI3K Cascade (Saccharomyces cerevisiae)
PI3K Cascade (Schizosaccharomyces pombe)
PI3K Cascade (Sus scrofa)
PI3K Cascade (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000449
,
BIOMD0000000883
Created
de Bono, B (2004-01-20)
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