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IRS-mediated signalling
Stable Identifier
R-HSA-112399
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
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Release of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
Participants
Events
p-Y-IRS1,p-Y-IRS2 bind PI3K
(Homo sapiens)
PI3K Cascade
(Homo sapiens)
SOS-mediated signalling
(Homo sapiens)
Participates
as an event of
Insulin receptor signalling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
Orthologous Events
IRS-mediated signalling (Bos taurus)
IRS-mediated signalling (Caenorhabditis elegans)
IRS-mediated signalling (Canis familiaris)
IRS-mediated signalling (Danio rerio)
IRS-mediated signalling (Dictyostelium discoideum)
IRS-mediated signalling (Drosophila melanogaster)
IRS-mediated signalling (Gallus gallus)
IRS-mediated signalling (Mus musculus)
IRS-mediated signalling (Plasmodium falciparum)
IRS-mediated signalling (Rattus norvegicus)
IRS-mediated signalling (Saccharomyces cerevisiae)
IRS-mediated signalling (Schizosaccharomyces pombe)
IRS-mediated signalling (Sus scrofa)
IRS-mediated signalling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000883
,
BIOMD0000000356
,
BIOMD0000000255
Authored
Charalambous, M (2004-04-29)
Created
Charalambous, M (2004-04-29)
© 2024
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