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Meiotic synapsis
Stable Identifier
R-HSA-1221632
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
,
nuclear envelope
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
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Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).
Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
18948708
The Mammalian synaptonemal complex: a scaffold and beyond
Wang, PJ
,
Yang, F
Genome Dyn
2009
20364103
DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis
Schoenmakers, S
,
Inagaki, A
,
Baarends, WM
Epigenetics
2010
Participants
Events
Formation of axial/lateral elements of Synaptonemal Complex
(Homo sapiens)
Telomeres cluster at the nuclear membrane
(Homo sapiens)
Synapsis
(Homo sapiens)
BRCA1 is recruited to unsynapsed regions
(Homo sapiens)
ATR Kinase is recruited to unsynapsed regions
(Homo sapiens)
ATR phosphorylates Histone H2A.X at unsynapsed regions
(Homo sapiens)
Participates
as an event of
Meiosis (Homo sapiens)
Authored
May, B (2011-02-25)
Reviewed
Bolcun-Filas, E (2011-02-25)
Lyndaker, A (2011-02-25)
Holloway, JK (2011-02-05)
Schimenti, JC (2011-02-05)
Strong, E (2011-02-25)
Cohen, PE (2011-02-05)
Created
May, B (2011-02-25)
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