Reactome | KCNK5 [plasma membrane]

KCNK5 [plasma membrane]

Stable Identifier

R-HSA-1296323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium channel subfamily K member 5 (TASK2), KCNK5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95279 KCNK5

Gene Names

KCNK5, TASK2

Chain

chain:1-499

Reference Genes

BioGPS Gene:8645 KCNK5

COSMIC (genes):KCNK5 KCNK5

CTD Gene:8645 KCNK5

dbSNP Gene:8645 KCNK5

ENSEMBL:ENSG00000164626 KCNK5

HGNC:6280 KCNK5

Monarch:8645 KCNK5

NCBI Gene:8645 KCNK5

OMIM:603493 KCNK5

UCSC:O95279 KCNK5

Reference Transcript

RefSeq:NM_003740.3 KCNK5

Other Identifiers

11723876_at

11723877_at

17018841

219615_PM_s_at

219615_s_at

240175_PM_at

240175_at

2952835

2952836

2952837

2952838

2952839

2952840

2952841

2952842

2952843

2952845

2952846

2952847

2952848

2952849

2952870

2952871

72628_at

74918_at

76463_at

8126153

8645

A_23_P319423

A_24_P346269

GE58310

GO:0005215

GO:0005249

GO:0005267

GO:0005515

GO:0005886

GO:0006813

GO:0015271

GO:0016020

GO:0022841

GO:0030322

GO:0034702

GO:0055085

GO:0060075

GO:0071805

GO:0097623

GO:1990573

HMNXSV003003234

Hs.235207.0.A1_3p_at

ILMN_1766918

PH_hs_0025965

TC06001696.hg

g4504850_3p_a_at

Participates

as a component of

KCNK5 dimer [plasma membrane] (Homo sapiens)

Inferred To

kcnk5a [plasma membrane] (Danio rerio)

TOK1 [plasma membrane] (Saccharomyces cerevisiae)

kcnk5 [plasma membrane] (Xenopus tropicalis)

Kcnk5 [plasma membrane] (Mus musculus)

Kcnk5 [plasma membrane] (Rattus norvegicus)

KCNK5 [plasma membrane] (Bos taurus)

KCNK5 [plasma membrane] (Canis familiaris)

KCNK5 [plasma membrane] (Gallus gallus)

KCNK5 [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

517

ENSEMBL

ENSP00000352527, ENST00000359534

OpenTargets

ENSG00000164626

HPA

ENSG00000164626-KCNK5

PRO

O95279

Pharos - Targets

O95279

GlyGen

O95279

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:O43169 CYB5B	2	CYB5B [endoplasmic reticulum membrane] (R-HSA-9842695) CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [plasma membrane] (R-HSA-53211)	0.556	3

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