Reactome | VAMP3 [phagocytic vesicle membrane]

VAMP3 [phagocytic vesicle membrane]

Stable Identifier

R-HSA-2029013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

Synonyms

Vesicle-associated membrane protein 3, VAMP3_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - ER-Phagosome pathway (Homo sapiens)
        
        Fusion of ERC and phagosome (Homo sapiens)
        
        p-S95-SNAP23:VAMP8,VAMP3 [phagocytic vesicle membrane] (Homo sapiens)
        
        VAMP8,VAMP3 [phagocytic vesicle membrane] (Homo sapiens)
        
        VAMP3 [phagocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15836 VAMP3

Gene Names

VAMP3, SYB3

Chain

initiator methionine:, chain:2-100

Reference Genes

BioGPS Gene:9341 VAMP3

COSMIC (genes):VAMP3 VAMP3

CTD Gene:9341 VAMP3

dbSNP Gene:9341 VAMP3

ENSEMBL:ENSG00000049245 VAMP3

ENSEMBL_homo_sapiens_GENE:ENSG00000049245.13 VAMP3

HGNC:12644 VAMP3

KEGG Gene (Homo sapiens):9341 VAMP3

Monarch:9341 VAMP3

NCBI Gene:9341 VAMP3

OMIM:603657 VAMP3

Reference Transcript

RefSeq:NM_004781.3 VAMP3

Other Identifiers

11716285_a_at

11716286_at

16658528

201336_PM_at

201336_at

201337_PM_s_at

201337_s_at

211749_PM_s_at

211749_s_at

2318638

2318642

2318647

2318649

2318652

2318653

2318654

2318655

35783_at

35784_at

7897370

9341

A_24_P370887

GE79979

GO:0001921

GO:0002376

GO:0005484

GO:0005515

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0005886

GO:0006887

GO:0006904

GO:0006906

GO:0007155

GO:0009986

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0017075

GO:0017156

GO:0023052

GO:0030133

GO:0030136

GO:0030141

GO:0030669

GO:0030670

GO:0031201

GO:0031410

GO:0031901

GO:0032588

GO:0034446

GO:0035493

GO:0042147

GO:0043001

GO:0043005

GO:0043226

GO:0043231

GO:0045202

GO:0045335

GO:0048471

GO:0051649

GO:0055037

GO:0055038

GO:0060090

GO:0061024

GO:0061025

GO:0065003

GO:0071346

GO:0072659

GO:0098542

GO:1903531

HMNXSV003032603

ILMN_1714527

PH_hs_0004058

TC01000099.hg

U64520_at

g13097737_3p_at

g13543573_3p_s_at

g9257252_3p_s_at

Participates

as a member of

VAMP8,VAMP3 [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

VAMP3 [recycling endosome membrane]

VAMP3 [plasma membrane]

VAMP3 [trans-Golgi network membrane]

VAMP3 [transport vesicle]

VAMP3 [clathrin-coated endocytic vesicle membrane]

Inferred To

Vamp3 [phagocytic vesicle membrane] (Mus musculus)

Vamp3 [phagocytic vesicle membrane] (Rattus norvegicus)

VAMP3 [phagocytic vesicle membrane] (Canis familiaris)

VAMP3 [phagocytic vesicle membrane] (Gallus gallus)

VAMP3 [phagocytic vesicle membrane] (Sus scrofa)

Cross References

RefSeq

NP_004772.1

OpenTargets

ENSG00000049245

GeneCards

Q15836

HPA

ENSG00000049245-VAMP3

Ensembl

ENSG00000049245, ENST00000054666, ENSP00000054666

PRO

Q15836

Pharos - Targets

Q15836

Interactors (87)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.884	10
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.742	5
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.725	7
UniProt:O00161 SNAP23	5	SNAP23 [phagocytic vesicle membrane] (R-HSA-8863966) p-S95-SNAP23 [phagocytic vesicle membrane] (R-HSA-8863923) SNAP23 [tertiary granule membrane] (R-HSA-6806141) SNAP23 [plasma membrane] (R-HSA-376345) SNAP23 [specific granule membrane] (R-HSA-6806157)	0.669	3
UniProt:Q9UNK0 STX8			0.643	6
UniProt:O15400 STX7			0.643	7
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.643	4
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.643	4
UniProt:Q8IWB7 WDFY1			0.643	3
UniProt:Q86Y82 STX12			0.643	6
UniProt:O55012	3	Picalm [Golgi membrane] (R-RNO-434341) Picalm [cytoplasmic vesicle membrane] (R-RNO-429812) Picalm [cytosol] (R-RNO-8867593)	0.558	2
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q53FP2 NACHO			0.556	3
UniProt:Q8TBP5 F174A			0.556	3
UniProt:Q9H7M9 VISTA			0.556	3
UniProt:O14524-2 NEMP1			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
IntAct:EBI-23184686 CCSB ORF ID			0.556	3
UniProt:J3KQ12 J3KQ12			0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:Q8IVF2-3 AHNAK2			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q6ZT21 TMPPE			0.556	3
UniProt:O14684 PTGES	1	PTGES [endoplasmic reticulum membrane] (R-HSA-2142717)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q86T13 CLC14			0.556	3
UniProt:Q86VR2 RETR3			0.556	3
UniProt:Q9NVV5-2 AIG1			0.556	3
UniProt:Q96DZ7 T4S19			0.556	3
UniProt:Q9H5X1 CIA2A			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q99735 MGST2	1	MGST2 [endoplasmic reticulum membrane] (R-HSA-176058)	0.556	3
UniProt:Q53GL0 PKHO1			0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [cell junction] (R-HSA-421241) CLDN7 [plasma membrane] (R-HSA-420004)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:O95279 KCNK5	1	KCNK5 [plasma membrane] (R-HSA-1296323)	0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:Q53R12 T4S20			0.556	3
UniProt:Q9NR31 SAR1A			0.556	3
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q13323 BIK			0.556	3
UniProt:P54852 EMP3			0.542	3
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:Q14108 SCARB2	2	SCARB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869106) SCARB2 [plasma membrane] (R-HSA-8864566)	0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	4
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	2
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	2
UniProt:Q9H813 PACC1			0.527	2
UniProt:O75558 STX11			0.527	3
UniProt:Q8N4C7 STX19			0.527	2
UniProt:Q96P53 WDFY2			0.527	2
UniProt:Q16563 SYPL1			0.527	2
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:Q9Y6L6 SLCO1B1	3	SLCO1B1 [plasma membrane] (R-HSA-194133) SLCO1B1 R253* [plasma membrane] (R-HSA-5661200) SLCO1B1 R580* [plasma membrane] (R-HSA-5661185)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q29983 MICA	1	MICA [plasma membrane] (R-HSA-5696432)	0.527	2
UniProt:P0DTD8 NS7B			0.527	2
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.527	2
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.527	2
UniProt:O14810 CPLX1	1	CPLX1 [cytosol] (R-HSA-210385)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:O43915 VEGFD	2	FIGF [platelet alpha granule lumen] (R-HSA-67161) FIGF [extracellular region] (R-HSA-139888)	0.488	4
UniProt:P11279 LAMP1	3	LAMP1 [ficolin-1-rich granule membrane] (R-HSA-6800966) LAMP1 [plasma membrane] (R-HSA-6806268) LAMP1 [azurophil granule membrane] (R-HSA-6799162)	0.483	4
UniProt:P62491 RAB11A	4	RAB11A [recycling endosome membrane] (R-HSA-2029023) GGC-RAB11A [cytosol] (R-HSA-8873781) RAB11A [cytosol] (R-HSA-5623395) GGC-RAB11A [cytoplasmic vesicle membrane] (R-HSA-1458519)	0.483	2
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.483	2

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