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CYB5B [mitochondrial outer membrane]
Stable Identifier
R-HSA-8943390
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Cytochrome b5 type B, CYB5B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3 [mitochondrial outer membrane] (Homo sapiens)
CYB5B [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43169 CYB5B
Gene Names
CYB5B, CYB5M, OMB5
Chain
propeptide:1-15, chain:16-150
Reference Genes
BioGPS Gene:80777 CYB5B
COSMIC (genes):CYB5B CYB5B
CTD Gene:80777 CYB5B
dbSNP Gene:80777 CYB5B
ENSEMBL:ENSG00000103018 CYB5B
HGNC:24374 CYB5B
KEGG:hsa:80777 CYB5B
Monarch:80777 CYB5B
NCBI Gene:80777 CYB5B
OMIM:611964 CYB5B
UCSC:O43169 CYB5B
Reference Transcript
RefSeq:NM_030579.2 CYB5B
Other Identifiers
11719093_at
11719094_x_at
11719095_s_at
11719096_at
16820592
201633_PM_s_at
201633_s_at
201634_PM_s_at
201634_s_at
227382_PM_at
227382_at
238554_PM_at
238554_at
34339_at
34340_at
3666721
3666733
3666734
3666740
3666741
3666742
3666743
3666744
3666745
3666746
3666747
3666752
3666753
3666754
3666755
3666756
3666757
3666758
3666759
3666760
3666761
3666762
3666763
3666774
3666775
55787_at
58032_at
62720_at
70487_at
7996947
80777
A_23_P206697
A_33_P3357535
GE53233
GE823610
GO:0003824
GO:0005515
GO:0005739
GO:0005741
GO:0005789
GO:0006805
GO:0006809
GO:0006979
GO:0008047
GO:0016020
GO:0016491
GO:0020037
GO:0043226
GO:0043231
GO:0046872
GO:0050421
GO:0098772
GO:1903958
HMNXSV003048036
Hs.60973.0.A1_3p_at
Hs.79103.0.S1_3p_a_at
Hs.79103.2.S1_3p_at
ILMN_1684321
PH_hs_0025903
PH_hs_0039925
TC16000569.hg
g13385593_3p_a_at
Participates
as a component of
MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3 [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
CYB5B [endoplasmic reticulum membrane]
Inferred To
cyb5B [mitochondrial outer membrane]
(Dictyostelium discoideum)
Homologues of CYB5B [mitochondrial outer membrane]
(Caenorhabditis elegans)
Homologues of CYB5B [mitochondrial outer membrane]
(Danio rerio)
Homologues of CYB5B [mitochondrial outer membrane]
(Dictyostelium discoideum)
Homologues of CYB5B [mitochondrial outer membrane]
(Drosophila melanogaster)
Dmel\CG3566 [mitochondrial outer membrane]
(Drosophila melanogaster)
Dmel\CG5157 [mitochondrial outer membrane]
(Drosophila melanogaster)
cyb5C [mitochondrial outer membrane]
(Dictyostelium discoideum)
CYB5B [mitochondrial outer membrane]
(Bos taurus)
CYB5B [mitochondrial outer membrane]
(Caenorhabditis elegans)
CYB5B [mitochondrial outer membrane]
(Canis familiaris)
CYB5B [mitochondrial outer membrane]
(Drosophila melanogaster)
CYB5B [mitochondrial outer membrane]
(Gallus gallus)
CYB5B [mitochondrial outer membrane]
(Mus musculus)
CYB5B [mitochondrial outer membrane]
(Rattus norvegicus)
CYB5B [mitochondrial outer membrane]
(Sus scrofa)
cyb5b [mitochondrial outer membrane]
(Danio rerio)
cyb5b [mitochondrial outer membrane]
(Xenopus tropicalis)
cyb5a [mitochondrial outer membrane]
(Danio rerio)
cytb-5.1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_085056.2
OpenTargets
ENSG00000103018
ENSEMBL
ENSP00000308430
,
ENST00000307892
HPA
ENSG00000103018-CYB5B
PRO
O43169
Pharos - Targets
O43169
GlyGen
O43169
HMDB Protein
HMDBP08642
PDB
3NER
Interactors (47)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUM3 S39A9
0.556
3
UniProt:O60238 BNIP3L
1
BNIP3L [mitochondrial outer membrane]
(R-HSA-6798001)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q5VUM1 SDHAF4
1
SDHAF4 [mitochondrial matrix]
(R-HSA-9854972)
0.556
3
UniProt:Q8N183 NDUFAF2
1
NDUFAF2 [mitochondrial inner membrane]
(R-HSA-5689129)
0.556
3
UniProt:Q13323 BIK
0.556
3
UniProt:Q5TF39 MFSD4B
1
NAGLT1 [plasma membrane]
(R-HSA-5216212)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:P20138 CD33
3
CD33 [tertiary granule membrane]
(R-HSA-6800959)
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
0.556
3
UniProt:Q86VR2 RETR3
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:P27105 STOM
4
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [tertiary granule membrane]
(R-HSA-6800960)
0.556
3
UniProt:Q8IVF2-3 AHNAK2
0.556
3
UniProt:Q96HV5 TM41A
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:O95279 KCNK5
1
KCNK5 [plasma membrane]
(R-HSA-1296323)
0.556
3
UniProt:Q9P2J2-2 Q9P2J22
0.556
3
UniProt:O95377 GJB5
1
GJB5 [endoplasmic reticulum membrane]
(R-HSA-190643)
0.556
3
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.556
3
UniProt:Q5SR56 MF14B
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [plasma membrane]
(R-HSA-420004)
CLDN7 [cell junction]
(R-HSA-421241)
0.556
3
IntAct:EBI-23184686 CCSB ORF ID
0.556
3
UniProt:Q6UXG8-3 Q6UXG83
0.556
3
UniProt:Q5T0T0 MARH8
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:P21579 SYT1
7
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q8IV31 TM139
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:Q53FP2 NACHO
0.556
3
UniProt:P15941-11 MUC1
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:Q99675 CGRF1
0.556
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q96KR7 PHAR3
0.556
3
UniProt:A2A2Y4 FRMD3
0.556
3
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.556
3
UniProt:P0DTD1-PRO_0000449625 REP
0.527
2
UniProt:Q99IB8-PRO_0000045601
0.499
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
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