Reactome | GRB7 events in ERBB2 signaling

GRB7 events in ERBB2 signaling

Stable Identifier

R-HSA-1306955

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Heterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262) (Fiddes et al. 1998), but the exact downstream signaling of this complex has not been elucidated. GRB7 can recruit SHC1 to the active ERBB2 complex, and contributes to ERBB2 signaling-induced RAS activation, which promotes cellular proliferation, but the exact mechanism has not been elucidated (Pradip et al. 2013). In addition, GRB7 can be phosphorylated by the integrin-activated PTK2 (FAK), leading to VAV2-dependent activation of RAC1 and promotion of cell migration. The exact mechanistic details of GRB7-induced RAC1 activation are not known (Pradip et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23593540	Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules Leyland-Jones, B, Bouzyk, M, Dey, N, Pradip, D	Am J Cancer Res	2013
9516479	Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3 Daly, RJ, Campbell, DH, Wallasch, C, Sasaki, H, Janes, PW, Fiddes, RJ, Sivertsen, SP	J Biol Chem	1998